Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital and Harvard University Medical School, Cambridge, MA 02138, USA.
Curr Psychiatry Rep. 2011 Oct;13(5):357-63. doi: 10.1007/s11920-011-0213-3.
Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioral disorder afflicting adults worldwide. This article is an update on the evidence supporting medications for adult ADHD, with particular emphasis on cardiovascular implications. Relevant clinical literature was sought using PubMed searches, with an emphasis on new reports from April 2009 to April 2011. This review describes the efficacy and general tolerability of stimulant and nonstimulant medications for adults with ADHD as seen in contemporary clinical trials. Cardiovascular response to medications for ADHD is primarily seen in heart rate and blood pressure elevations, while less is known about the etiology of rare cardiovascular events or long-term sequelae. Further research is indicated to delineate clinical and functional outcomes for adults with ADHD, as well as long-term safety of medication treatment.
注意缺陷多动障碍（ADHD）是一种影响全球成年人的慢性神经行为障碍。本文是对支持成人 ADHD 药物治疗的证据的更新，特别强调心血管方面的影响。使用 PubMed 搜索寻找相关临床文献，重点关注 2009 年 4 月至 2011 年 4 月的新报告。本综述描述了在当代临床试验中，兴奋剂和非兴奋剂药物治疗成人 ADHD 的疗效和总体耐受性。ADHD 药物治疗的心血管反应主要表现为心率和血压升高，而对于罕见心血管事件或长期后果的病因了解较少。需要进一步研究来描绘 ADHD 成人的临床和功能结局，以及药物治疗的长期安全性。
