Origüela Valentina, Lopez-Zaplana Alvaro
Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
R&D Department, 3A Biotech, 30565 Murcia, Spain.
Microorganisms. 2025 May 7;13(5):1084. doi: 10.3390/microorganisms13051084.
The importance of the microbiome, particularly the gut microbiota and its implications for health, is well established. However, an increasing number of studies further strengthen the link between an imbalanced gut microbiota and a greater predisposition to different diseases. The gut microbiota constitutes a fundamental ecosystem for maintaining human health. Its alteration, known as dysbiosis, is associated with a wide range of conditions, including intestinal, metabolic, immunological, or neurological pathologies, among others. In recent years, there has been a substantial increase in knowledge about probiotics-bacterial species that enhance health or address various diseases-with numerous studies reporting their benefits in preventing or improving these conditions. This review aims to analyze the most common pathologies resulting from an imbalance in the gut microbiota, as well as detail the most important and known gut probiotics, their functions, and mechanisms of action in relation to these conditions.
微生物群,尤其是肠道微生物群及其对健康的影响,其重要性已得到充分确立。然而,越来越多的研究进一步加强了肠道微生物群失衡与更容易患不同疾病之间的联系。肠道微生物群是维持人类健康的重要生态系统。其改变,即生态失调,与多种疾病有关,包括肠道、代谢、免疫或神经病理学等。近年来,人们对益生菌(即能增进健康或治疗各种疾病的细菌种类)的了解大幅增加,众多研究报告了它们在预防或改善这些疾病方面的益处。本综述旨在分析肠道微生物群失衡导致的最常见疾病,并详细介绍最重要且广为人知的肠道益生菌、它们的功能以及与这些疾病相关的作用机制。