Department of Nutritional Sciences, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Br J Nutr. 2010 Jun;103(12):1778-83. doi: 10.1017/S0007114509993801. Epub 2010 Jan 26.
Many studies have been done on the hypocholesterolaemic effect of probiotic yoghurt. The results, however, are not conclusive. The aim of the present study was to test the effect of probiotic and conventional yoghurt on the lipid profile in women. In a randomised trial, ninety female volunteers aged 19-49 years were assigned to three groups. Subjects consumed daily 300 g probiotic yoghurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g conventional yoghurt or no yoghurt for 6 weeks. Fasting blood samples, 3 d dietary records and anthropometric measurements were collected at baseline (T1), end of week 3 (T2) and end of week 6 (T3). Lipid profile parameters were determined by enzymic methods. Results showed no significant difference in lipid profile within any group throughout the study. Comparing mean differences (T1 - T3) among the three groups showed: no difference in TAG and LDL-cholesterol, a decrease in cholesterol in both conventional (P < 0.05) and probiotic yoghurt groups (P < 0.005) compared with the control group, a decrease in total:HDL-cholesterol ratio for conventional (P < 0.05) and probiotic yoghurt groups (P < 0.001) compared with the control group, and an increase in HDL-cholesterol in the probiotic yoghurt group (P < 0.05) compared with the control group. Positive changes in lipid profile were observed in both yoghurt groups. Any added effect, therefore, is due to the consumption of fermented milk products.
许多研究都探讨了益生菌酸奶的降胆固醇作用。然而，结果并不确定。本研究的目的是测试益生菌和传统酸奶对女性血脂谱的影响。在一项随机试验中，将 90 名 19-49 岁的女性志愿者分为三组。受试者每天食用 300g 含有嗜酸乳杆菌 La5 和双歧杆菌 Bb12 的益生菌酸奶或 300g 传统酸奶或不食用酸奶，持续 6 周。在基线（T1）、第 3 周末（T2）和第 6 周末（T3）采集空腹血样、3 天饮食记录和人体测量数据。采用酶法测定血脂谱参数。结果显示，在整个研究过程中，任何一组的血脂谱参数均无显著差异。比较三组之间的平均差异（T1-T3）：常规酸奶组和益生菌酸奶组的 TAG 和 LDL-胆固醇无差异（P<0.05），与对照组相比，胆固醇降低（P<0.05），常规酸奶组和益生菌酸奶组总胆固醇：HDL-胆固醇比值降低（P<0.05），与对照组相比，益生菌酸奶组 HDL-胆固醇升高（P<0.05）。两组酸奶均观察到血脂谱的积极变化。因此，任何额外的效果都归因于发酵乳制品的摄入。
