Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition. 2012 May;28(5):539-43. doi: 10.1016/j.nut.2011.08.013. Epub 2011 Nov 29.
Oxidative stress plays a major role in the pathogenesis and progression of diabetes. Among various functional foods with an antioxidant effect, probiotic foods have been reported to repress oxidative stress. The objective of this clinical trial was to assess the effects of probiotic and conventional yogurt on blood glucose and antioxidant status in type 2 diabetic patients.
Sixty-four patients with type 2 diabetes mellitus, 30 to 60 y old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group consumed 300 g/d of conventional yogurt for 6 wk. Fasting blood samples, 24-h dietary recalls, and anthropometric measurements were collected at the baseline and at the end of the trial.
Probiotic yogurt significantly decreased fasting blood glucose (P < 0.01) and hemoglobin A1c (P < 0.05) and increased erythrocyte superoxide dismutase and glutathione peroxidase activities and total antioxidant status (P < 0.05) compared with the control group. In addition, the serum malondialdehyde concentration significantly decreased compared with the baseline value in both groups (P < 0.05). No significant changes from baseline were shown in insulin concentration and erythrocyte catalase activity within either group (P > 0.05).
The consumption of probiotic yogurt improved fasting blood glucose and antioxidant status in type 2 diabetic patients. These results suggest that probiotic yogurt is a promising agent for diabetes management.
氧化应激在糖尿病的发病机制和进展中起着重要作用。在具有抗氧化作用的各种功能性食品中，益生菌食品已被报道能抑制氧化应激。本临床试验的目的是评估益生菌和常规酸奶对 2 型糖尿病患者血糖和抗氧化状态的影响。
将 64 名年龄在 30 至 60 岁之间的 2 型糖尿病患者随机分为两组，进行双盲对照临床试验。干预组患者每天食用 300 克含有嗜酸乳杆菌 La5 和双歧杆菌 Bb12 的益生菌酸奶，对照组患者每天食用 300 克常规酸奶，持续 6 周。在基线和试验结束时收集空腹血样、24 小时膳食回忆和人体测量数据。
与对照组相比，益生菌酸奶显著降低了空腹血糖（P < 0.01）和糖化血红蛋白（P < 0.05），并增加了红细胞超氧化物歧化酶和谷胱甘肽过氧化物酶活性以及总抗氧化状态（P < 0.05）。此外，两组血清丙二醛浓度均较基线值显著降低（P < 0.05）。两组胰岛素浓度和红细胞过氧化氢酶活性均无明显变化（P > 0.05）。
食用益生菌酸奶改善了 2 型糖尿病患者的空腹血糖和抗氧化状态。这些结果表明，益生菌酸奶是一种有前途的糖尿病管理药物。
