Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania.
Colloids Surf B Biointerfaces. 2011 Oct 15;87(2):382-90. doi: 10.1016/j.colsurfb.2011.05.046. Epub 2011 Jun 22.
The study presents the preparation of a semi-synthetic hydrogel based on poly(N-isopropyl acrylamide-co-diethylene glycol diacrylate) inserted onto the collagen porous membrane. The synthesis of the hydrogels was performed through radical copolymerization of N-isopropyl acrylamide (NIPAM) with diethylene glycol diacrylate (DEGDA) also as crosslinking agent, using ammonium persulfate as initiator and N,N,N',N'-tetramethylethylene diamine as activator, and it was achieved in the presence of the collagen matrix. The prepared hydrogels were characterized by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy. The swelling behaviour of the semi-interpenetrated polymer network related on the hydrogel composition, it was also evaluated. The pore sizes of the synthesized hydrogels, much larger than the typical mesh size of a conventional hydrogel, allow to consider the hybrid hydrogel based on the inserted poly(NIPAM-co-DEGDA) onto collagen fibrils as a super-porous hydrogel.
本研究提出了一种基于聚（N-异丙基丙烯酰胺-co-二乙二醇二丙烯酸酯）的半合成水凝胶的制备方法，该水凝胶插入到胶原多孔膜中。水凝胶的合成是通过 N-异丙基丙烯酰胺（NIPAM）与二乙二醇二丙烯酸酯（DEGDA）的自由基共聚来实现的，同时 DEGDA 也作为交联剂，使用过硫酸铵作为引发剂，N,N,N',N'-四甲基乙二胺作为活性剂，并在胶原基质的存在下进行。所制备的水凝胶通过衰减全反射傅里叶变换红外光谱和扫描电子显微镜进行了表征。还评估了半互穿聚合物网络的溶胀行为与水凝胶组成的关系。合成水凝胶的孔径远大于常规水凝胶的典型网格尺寸，这使得基于插入到胶原纤维上的聚（NIPAM-co-DEGDA）的杂化水凝胶可以被认为是一种超多孔水凝胶。
