Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-Cho, Koganei 184-8588, Japan.
Biomolecules. 2023 Feb 2;13(2):280. doi: 10.3390/biom13020280.
Hydrogels are being investigated for their application in inducing the regeneration of various tissues, and suitable conditions for each tissue are becoming more apparent. Conditions such as the mechanical properties, degradation period, degradation mechanism, and cell affinity can be tailored by changing the molecular structure, especially in the case of polymers. Furthermore, many high-functional hydrogels with drug delivery systems (DDSs), in which drugs or bioactive substances are contained in controlled hydrogels, have been reported. This review focuses on the molecular design and function of biopolymer-based hydrogels and introduces recent developments in functional hydrogels for clinical applications.
水凝胶因其在诱导各种组织再生方面的应用而受到研究关注，并且每种组织的合适条件变得越来越明显。通过改变分子结构（特别是在聚合物的情况下），可以调整诸如机械性能、降解周期、降解机制和细胞亲和力等条件。此外，已经报道了许多具有药物传递系统（DDS）的高功能水凝胶，其中将药物或生物活性物质包含在受控水凝胶中。本综述重点介绍了基于生物聚合物的水凝胶的分子设计和功能，并介绍了用于临床应用的功能性水凝胶的最新进展。
