Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, United States.
Curr Opin Biotechnol. 2011 Aug;22(4):502-8. doi: 10.1016/j.copbio.2011.05.508. Epub 2011 Jun 21.
Label-free sensing technologies have recently attracted a great deal of interest for sensitive, rapid and facile analysis for applications in health care, environmental monitoring, food safety and homeland security. One-dimensional (1-D) nanostructures such as nanowires, configured as field-effect transistors (FETs)/chemiresistors that change conductance upon binding of charged macromolecules to receptors linked to the device surfaces are extremely attractive for label-free biosensors. Herein, we review recent advances in label-free biosensors based on conducting polymer nanowires based FET/chemiresistor. Specifically, we address the fabrication, functionalization, assembly/alignment and sensing applications of FET/chemiresistor based on these nanomaterials. The advantages and disadvantages of various fabrication, functionalization, and assembling procedures of these nanosensors are reviewed and discussed.
无标记传感技术最近受到了极大的关注，因为它可以用于医疗保健、环境监测、食品安全和国土安全等领域的敏感、快速和简便的分析。一维（1-D）纳米结构，如纳米线，被配置为场效应晶体管（FET）/化学电阻器，当与器件表面相连的受体结合带电荷的大分子时，其电导会发生变化，因此非常适合用于无标记生物传感器。在此，我们综述了基于导电聚合物纳米线的 FET/化学电阻器的无标记生物传感器的最新进展。具体来说，我们讨论了基于这些纳米材料的 FET/化学电阻器的制造、功能化、组装/对准和传感应用。我们还综述和讨论了这些纳米传感器的各种制造、功能化和组装过程的优缺点。
