基于一维纳米结构的生物检测。

One-dimensional nanostructures based bio-detection.

机构信息

Department of Chemical and Environmental Engineering and Center for Nanoscale Science and Engineering, University of California-Riverside, Riverside, CA 92521, United States.

Department of Fusion Chemical Engineering, Hanyang University, Ansan, Kyeonggi-do 426-791, Korea.

出版信息

Biosens Bioelectron. 2015 Jan 15;63:432-443. doi: 10.1016/j.bios.2014.07.043. Epub 2014 Jul 24.

DOI:10.1016/j.bios.2014.07.043

PMID:25128623

Abstract

This paper presents a review on recent developments of one-dimensional (1-D) nanostructures based label-free chemiresistive/chemFET biosensors and the various sensing mechanisms used for biomolecular detection. The sensor performance including sensitivity, selectivity, and reliability is compared in terms of material synthesis of the sensor's element, relating surface functionalization schemes to their properties with respect to selected bioreceptors, its method of fabrication, and its intended operation. As a final point, we outline the prospects of chemiresistive/chemFET biosensors and recommend specific advancements in this field.

摘要

本文综述了近年来一维（1-D）纳米结构无标记化学电阻/场效应晶体管（chemFET）生物传感器的最新发展，以及用于生物分子检测的各种传感机制。从传感器元件的材料合成、与选定生物受体相关的表面功能化方案及其性能、制造方法及其预期操作等方面，比较了传感器的性能，包括灵敏度、选择性和可靠性。最后，我们概述了化学电阻/chemFET 生物传感器的前景，并对该领域的具体进展提出了建议。