Brown R C, Carthew P, Hoskins J A, Sara E, Simpson C F
MRC Toxicology Unit, Carshalton, Surrey, UK.
Carcinogenesis. 1990 Oct;11(10):1883-5. doi: 10.1093/carcin/11.10.1883.
A sample of amosite asbestos was modified by effectively adding C8 and C18 hydrocarbon chains to the fibre surfaces. The altered fibres interacted less readily with cells in vitro and were less cytotoxic. In whole animals the number of mesotheliomas produced by the C8 material was the same as that with the parent material but the tumours occurred earlier. The C18 derivatized fibre was markedly less active in the production of tumours. This is the first report demonstrating that similar size fibres with differing surfaces have different pathogenic properties.
对铁石棉样本进行改性，通过向纤维表面有效添加C8和C18烃链。改性后的纤维在体外与细胞的相互作用较弱，细胞毒性也较小。在整体动物中，C8材料诱发的间皮瘤数量与母体材料相同，但肿瘤出现得更早。C18衍生纤维诱发肿瘤的活性明显较低。这是第一份表明表面不同但尺寸相似的纤维具有不同致病特性的报告。
