Department of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
J Am Soc Nephrol. 2011 Jul;22(7):1208-12. doi: 10.1681/ASN.2010101018. Epub 2011 Jun 23.
Successful regenerative renal medicine depends on understanding the molecular mechanisms by which diverse phenotypes of epithelial cells differentiate from metanephric mesenchyme to populate nephrons. Whereas many genes are maintained in a poised state within the population of pluripotent progenitors, specialized epithelial functions reflect the selective expression of a subset of genes and the repression of all others. Here we highlight some common mechanisms of cell differentiation and epigenetic regulation to discuss their implications for renal epithelial development, repair, and disease.
成功的再生肾脏医学取决于理解不同表型的上皮细胞从后肾间充质分化以填充肾单位的分子机制。虽然许多基因在多能祖细胞群体中保持在一个平衡状态，但专门的上皮功能反映了一组基因的选择性表达和其他所有基因的抑制。在这里，我们强调一些细胞分化和表观遗传调控的共同机制，以讨论它们对肾脏上皮发育、修复和疾病的影响。
