构建复杂器官：肾脏发育中的分支形态发生和肾单位分段。
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.
机构信息
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
出版信息
Dev Cell. 2010 May 18;18(5):698-712. doi: 10.1016/j.devcel.2010.04.008.
Abstract
The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesce into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas.
摘要
肾脏的两个主要组成部分，即收集系统和肾单位，具有不同的发育历史。收集系统通过简单上皮管的反复分支而产生，而肾单位则由融合成上皮小泡的间质细胞云形成。每个都发育成形态复杂且高度分化的结构，它们共同提供必要的过滤和吸收功能。在这篇综述中，我们将考虑它们的胚胎起源以及控制其形态发生、模式形成和分化的基因，重点关注几个领域的最新进展。
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