同种异体反应性的生物学意义：被仙台病毒包被的同基因细胞刺激的T细胞特异性裂解异基因靶细胞。
Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.
作者信息
Finberg R, Burakoff S J, Cantor H, Benacerraf B
出版信息
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5145-9. doi: 10.1073/pnas.75.10.5145.
Abstract
In vitro stimulation of spleen cells from mice immune to Sendai virus results in the generation of effector cells that lyse unmodified allogeneic target cells in addition to syngeneic cells modified by virus. These cells are immunologically specific because their lysis may be blocked by cold targets syngeneic to either the stimulator or the responder. These results support our proposal that the development of alloreactivity can be explained by the crossreactivity between modified self major histocompatibility complex antigens and alloantigens. We propose that exposure to autologous major histocompatibility complex antigens modified by foreign antigens in our environment results in the expansion of the pool of T cells that will respond to alloantigens sharing crossreactive determinants.
摘要
用仙台病毒免疫的小鼠脾细胞进行体外刺激，可产生效应细胞，这些效应细胞除了能裂解经病毒修饰的同基因细胞外，还能裂解未修饰的异基因靶细胞。这些细胞具有免疫特异性，因为它们的裂解作用可被与刺激细胞或应答细胞同基因的冷靶细胞所阻断。这些结果支持了我们的提议，即同种异体反应性的产生可以通过修饰的自身主要组织相容性复合体抗原与同种异体抗原之间的交叉反应来解释。我们提出，在我们的环境中，接触经外来抗原修饰的自体主要组织相容性复合体抗原会导致对共享交叉反应决定簇的同种异体抗原产生反应的T细胞库扩大。
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Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.同种异体反应性的生物学意义：被仙台病毒包被的同基因细胞刺激的T细胞特异性裂解异基因靶细胞。
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5145-9. doi: 10.1073/pnas.75.10.5145.
2
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Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.对同种异体刺激细胞具有特异性的溶细胞性胸腺来源淋巴细胞与化学修饰的同基因细胞发生交叉反应。
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Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex.细胞毒性T细胞对灭活仙台病毒和主要组织相容性复合体产物的联合识别。
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