Saint Josephs Research Institute, Mercer University School of Pharmaceutical Sciences, Atlanta, Georgia, USA.
J Occup Environ Med. 2011 Jul;53(7):758-64. doi: 10.1097/JOM.0b013e31821f64c3.
To determine the association of cardiovascular risk markers with noninvasive imaging of atherosclerosis in firefighters.
Cross-sectional investigation of subclinical atherosclerosis with metabolic, work related, and life-style variables in 296 professional firefighters.
Calcified coronary atherosclerosis (CAC), carotid arterial intimal thickness (CIMT), and electrocardiogram provided independent CVD assessments. Homeostatic Model Assessment (HOMA) concentrations were related to heart-rate-corrected QT (QTc) (slope ± SE: 2.16 ± 65, P = 0.001), average common CIMT (0.019 ± 0.005 mm, P = 0.0005), and total CAC lesions (0.269 ± 0.116, P = 0.02). Stepwise linear regression selected fasting insulin as the strongest predictor for QTc, HOMA as the strongest predictor of average CIMT, and fasting glucose as the strongest predictor of total coronary lesion number and score.
Firemen's HOMA and fasting insulin and glucose concentrations were significantly associated with three measures of CVD. Aspects of insulin resistance are related to CVD risk among firefighters.
确定心血管风险标志物与消防员动脉粥样硬化无创影像学之间的关系。
对 296 名职业消防员进行亚临床动脉粥样硬化的横断面研究，包括代谢、与工作相关和生活方式的变量。
钙化冠状动脉粥样硬化（CAC）、颈动脉内膜中层厚度（CIMT）和心电图提供了独立的心血管疾病评估。稳态模型评估（HOMA）浓度与心率校正 QT（QTc）有关（斜率±SE：2.16±65，P=0.001），平均普通 CIMT（0.019±0.005 mm，P=0.0005）和总 CAC 病变（0.269±0.116，P=0.02）。逐步线性回归选择空腹胰岛素作为 QTc 的最强预测因子，HOMA 作为平均 CIMT 的最强预测因子，空腹血糖作为总冠状动脉病变数量和评分的最强预测因子。
消防员的 HOMA 和空腹胰岛素及血糖浓度与心血管疾病的三项测量指标显著相关。胰岛素抵抗的某些方面与消防员的心血管疾病风险有关。
