Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA.
Curr Atheroscler Rep. 2011 Oct;13(5):396-404. doi: 10.1007/s11883-011-0198-8.
Coronary heart disease (CHD) often presents suddenly with little warning. Traditional risk factors are inadequate to identify the asymptomatic high-risk individuals. Early identification of patients with subclinical coronary artery disease using noninvasive imaging modalities would allow the early adoption of aggressive preventative interventions. Currently, it is impractical to screen the entire population with noninvasive coronary imaging tools. The use of relatively simple and inexpensive genetic markers of increased CHD risk can identify a population subgroup in which benefit of atherosclerotic imaging modalities would be increased despite nominal cost and radiation exposure. Additionally, genetic markers are fixed and need only be measured once in a patient's lifetime, can help guide therapy selection, and may be of utility in family counseling.
冠心病（CHD）常突然发作，且预警不足。传统的风险因素不足以识别无症状的高危个体。使用非侵入性成像方式早期识别亚临床冠状动脉疾病患者，将允许早期采取积极的预防干预措施。目前，使用非侵入性冠状动脉成像工具对整个人群进行筛查是不切实际的。使用相对简单和廉价的增加 CHD 风险的遗传标志物，可以识别出亚组人群，尽管名义上的成本和辐射暴露增加，但动脉粥样硬化成像方式的获益也会增加。此外，遗传标志物是固定的，患者一生中只需测量一次，有助于指导治疗选择，并且在家庭咨询中可能有用。
