Endocrinology and Nutrition Service, Hospital Carlos Haya, Malaga, Spain.
PLoS One. 2011;6(6):e21198. doi: 10.1371/journal.pone.0021198. Epub 2011 Jun 20.
The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1).
We investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain.
We undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from samples of cooking oil taken from the participants' kitchens and analyzed by gas chromatography. Five SNPs of the ELOVL6 gene were analyzed by SNPlex.
Carriers of the minor alleles of the SNPs rs9997926 and rs6824447 had a lower risk of having high HOMA_IR, whereas carriers of the minor allele rs17041272 had a higher risk of being insulin resistant. An interaction was detected between the rs6824447 polymorphism and the intake of oil in relation with insulin resistance, such that carriers of this minor allele who consumed sunflower oil had lower HOMA_IR than those who did not have this allele (P = 0.001).
Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
长链脂肪酸延长酶 6 家族（ELOVL6）是一种特异性催化 12、14 和 16 个碳原子的饱和和单不饱和脂肪酸延长的酶。ELOVL6 在生脂组织中表达，并受固醇调节元件结合蛋白 1（SREBP-1）调节。
我们研究了西班牙南部人群中 ELOVL6 遗传变异与胰岛素敏感性的关系。
我们进行了一项前瞻性的、基于人群的研究，收集表型、代谢、营养和遗传信息。测量体重和身高，并计算体重指数（BMI）。通过稳态模型评估测量胰岛素抵抗。从参与者厨房中采集食用油样本并通过气相色谱分析来评估膳食脂肪的类型。通过 SNPlex 分析 ELOVL6 基因的 5 个 SNP。
rs9997926 和 rs6824447 这两个 SNP 的次要等位基因携带者发生高 HOMA_IR 的风险较低，而 rs17041272 次要等位基因携带者发生胰岛素抵抗的风险较高。rs6824447 多态性与油的摄入量之间存在交互作用，与该等位基因携带者相比，摄入葵花籽油的携带者的 HOMA_IR 较低（P=0.001）。
这项基于人群的研究表明，ELOVL6 基因的遗传变异与胰岛素敏感性相关。
