Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, Mexico.
Código 46 SA de CV, Cuernavaca, Morelos 62498, Mexico.
Nutrients. 2020 Nov 4;12(11):3389. doi: 10.3390/nu12113389.
The elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work focused on the study of ELOVL polymorphs with clinical markers of non-communicable chronic diseases in the Mexican population. A sample of 1075 participants was obtained, who underwent clinical, biochemical, and nutritional evaluation, and a genetic evaluation of 91 genetic variants of ELOVL was considered (2-7). The results indicate a 33.16% prevalence of obesity by body mass index, 13.84% prevalence of insulin resistance by homeostatic model assessment (HOMA) index, 7.85% prevalence of high cholesterol, and 20.37% prevalence of hypercholesterolemia. The deprived alleles showed that there is no association between them and clinical disease risk markers, and the notable finding of the association studies is that the ELOVL2 variants are exclusive in men and ELVOL7 in women. There is also a strong association of ELOVL6 with various markers. The present study shows, for the first time, the association between the different ELOVLs and clinical markers of chronic non-communicable diseases.
非常长链脂肪酸延长酶（ELOVL）是一个由七种酶组成的家族，它们在脂肪酸的合成中具有特定的功能。有些酶已被证明与胰岛素分泌（ELOVL2）有关，而在脂质谱（ELOVL6）和各种病理患者中。本工作重点研究了具有非传染性慢性疾病临床标志物的墨西哥人群中的 ELOVL 多态性。获得了 1075 名参与者的样本，他们接受了临床、生化和营养评估，并考虑了 91 种 ELOVL 遗传变异的遗传评估（2-7）。结果表明，体重指数肥胖的患病率为 33.16%，稳态模型评估（HOMA）指数胰岛素抵抗的患病率为 13.84%，胆固醇高的患病率为 7.85%，高胆固醇血症的患病率为 20.37%。剥夺等位基因表明它们与临床疾病风险标志物之间没有关联，关联研究的显著发现是 ELOVL2 变体仅存在于男性中，ELVOL7 仅存在于女性中。ELOVL6 与各种标志物也有很强的关联。本研究首次显示了不同 ELOVL 与慢性非传染性疾病的临床标志物之间的关联。
