Ghosh Arijit, Dhumal V R, Tilak A V, Das Nina, Singh Amarinder, Bondekar Abhijit A
Department of Pharmacology, N.R.S. Medical College, Kolkata, India.
J Pharmacol Pharmacother. 2011 Jan;2(1):3-6. doi: 10.4103/0976-500X.77079.
To evaluate the nootropic and neuroprotective effects of aspirin in Sprague Dawley rats.
Retention of conditioned avoidance response (CAR) and central 5-HT-mediated behavior (lithium-induced head twitches) were assessed using repeated electroconvulsive shock (ECS) in rats. Rats were divided into eight groups: control (pretreated with distilled water), scopolamine (0.5 mg/kg i.p.), ECS (150 V, 50 Hz sinusoidal with intensity of 210 mA for 0.5 s) pretreated, aspirin (6.75 mg/kg orally) pretreated, combined scopolamine and aspirin pretreated, ondansetron (0.36 mg/kg orally) pretreated, combined ECS and ondansetron pretreated and combined ECS and aspirin pretreated groups. Data was analyzed by the chi-square test and ANOVA.
Findings show that administration of single ECS daily for consecutive 8 days results in enhancement of 5-HT-mediated behavior (lithium-induced head twitches) and in disruption of the retention of CAR. Aspirin and ondansetron administration significantly increased the retention of conditioned avoidance response compared to control. Ondansetron and aspirin significantly prevented ECS-induced attenuation of the retention of conditioned avoidance response also. On the other hand, ondansetron and aspirin significantly retarded the ECS-induced enhancement of 5-HT-mediated behavior.
Inhibition of the serotonergic transmission by aspirin is responsible for its nootropic and neuroprotective actions.
评估阿司匹林对斯普拉格-道利大鼠的促智和神经保护作用。
使用重复电惊厥休克（ECS）评估大鼠的条件性回避反应（CAR）保留情况和中枢5-羟色胺介导的行为（锂诱导的头部抽搐）。大鼠分为八组：对照组（用蒸馏水预处理）、东莨菪碱组（腹腔注射0.5mg/kg）、ECS预处理组（150V，50Hz正弦波，强度210mA，持续0.5秒）、阿司匹林预处理组（口服给药6.75mg/kg）、东莨菪碱与阿司匹林联合预处理组、昂丹司琼预处理组（口服给药0.36mg/kg）、ECS与昂丹司琼联合预处理组以及ECS与阿司匹林联合预处理组。数据采用卡方检验和方差分析进行分析。
研究结果表明，连续8天每日给予单次ECS会导致5-羟色胺介导的行为（锂诱导的头部抽搐）增强以及条件性回避反应保留受到破坏。与对照组相比，给予阿司匹林和昂丹司琼可显著提高条件性回避反应的保留率。昂丹司琼和阿司匹林还可显著预防ECS诱导的条件性回避反应保留率的降低。另一方面，昂丹司琼和阿司匹林可显著抑制ECS诱导的5-羟色胺介导行为的增强。
阿司匹林对血清素能传递的抑制作用是其促智和神经保护作用的原因。
