Limebeer C L, Parker L A
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
J Exp Psychol Anim Behav Process. 2000 Oct;26(4):371-84. doi: 10.1037//0097-7403.26.4.371.
Conditioned rejection reactions displayed in the taste reactivity test are exclusively produced by treatments that elicit nausea. The present experiments demonstrate that pretreatment with the antinausea agent ondansetron interferes with both the establishment and the expression of conditioned rejection reactions. Ondansetron did not interfere with lithium-induced taste avoidance in either a 1-bottle or a 2-bottle test. In fact, when rejection reactions were measured during a consumption test, ondansetron selectively attenuated rejection reactions, with only a slight modification of consumption. These results suggest that conditioned rejection reactions, but not conditioned taste avoidance, reflect nausea in rats that can be attenuated by ondansetron pretreatment.
味觉反应测试中显示的条件性拒斥反应完全由引发恶心的处理产生。本实验表明，用抗恶心药物昂丹司琼预处理会干扰条件性拒斥反应的建立和表达。在单瓶或双瓶测试中，昂丹司琼均不干扰锂诱导的味觉回避。事实上，在消耗测试中测量拒斥反应时，昂丹司琼选择性地减弱了拒斥反应，而对消耗仅有轻微影响。这些结果表明，条件性拒斥反应而非条件性味觉回避反映了大鼠的恶心，且这种恶心可通过昂丹司琼预处理减轻。
