[The effect of hypertonic saline solutions on water-salt metabolism in Brattleboro rats].

The role of antidiuretic hormone in the organism ability to resist against considerable salt shifts, was studied in Wistar (1st group) and Brattleboro rats--heterozygotes (2nd group). 5% NaCl solution was infused into animals' stomach (30-50-70-100 ml/kg). An increase in diuresis especially at 7-10% load, and a decrease in Na and K excretion occurred in Brattleboro rats. A decrease in tissue cation accumulation was found in Brattleboro rats as compared to Wistar ones. The Brattleboro rats with a partial defect of ADH synthesis revealed a decrease in the reserve possibilities of the system regulating the water-salt metabolism. As a result, 100% of Brattleboro rats died after 100 ml/kg salt load whereas the mortality in Wistar rats was only 22.2%.