Joglekar M V, Parekh V S, Hardikar A A
Stem Cells and Diabetes Section, National Center for Cell Science, Ganeshkhind, Pune 411007, India.
Indian J Exp Biol. 2011 Jun;49(6):401-8.
Diabetes is a chronic and slowly progressive disease that is presently reaching epidemic proportions in several parts of the world. Multiple aspects including genetic and lifestyle changes have been identified as the key factors leading to the development of type 1 and type 2 diabetes. Although molecular mechanisms underlying the pathogenesis of diabetes remain unclear, recent discoveries in understanding post-transcriptional gene regulation by microRNAs (miRNAs) has opened a new area of research. MicroRNAs have been implicated as new players in pathogenesis as well as complications of diabetes. MiRNAs have been shown to be necessary not only during embryonic development of insulin-producing cells, transcription of (pro-)insulin gene and insulin secretion, but also in development of insulin resistance and diabetes. The present review summarizes the findings related to understanding the role of miRNAs in endocrine pancreas development, pancreas regeneration, islet function and diabetes.
糖尿病是一种慢性且进展缓慢的疾病，目前在世界上多个地区正呈流行态势。包括遗传和生活方式改变在内的多个方面已被确定为导致1型和2型糖尿病发生的关键因素。尽管糖尿病发病机制的分子机制仍不清楚，但最近在理解微小RNA（miRNA）对转录后基因调控方面的发现开辟了一个新的研究领域。微小RNA已被认为是糖尿病发病机制及并发症中的新参与者。研究表明，微小RNA不仅在胰岛素生成细胞的胚胎发育、（前）胰岛素基因的转录和胰岛素分泌过程中是必需的，而且在胰岛素抵抗和糖尿病的发展过程中也是必需的。本综述总结了有关理解微小RNA在内分泌胰腺发育、胰腺再生、胰岛功能和糖尿病中作用的相关研究结果。
