Khan Ehtesham I, Kamal Rehana S, Ullah Hameed
Department of Anaesthesia & Intensive Care, Aga Khan University, Karachi, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Apr-Jun;22(2):4-7.
It is well documented that surgery is associated with increased anxiety, which has an adverse impact on patient's outcome. This study was designed to assess the anxiolytic effect of midazolam in pre-anaesthetic medication by using clinical and platelet aggregation profiles.
Sixty ASA I and II female patients aged between 35 and 60 years undergoing elective abdominal hysterectomy were randomly divided into two equal groups. Group I received placebo as pre-medication while group II received 0.15 mg/kg midazolam as pre-medication 1 hour preoperatively. They were monitored for visual analogue scale (VAS) for anxiety, observer's anxiety criteria, sedation score, blood pressure, heart rate and platelet aggregation profile immediately before and 1 hour after pre-medication.
There was statistically significant difference with respect to VAS of anxiety, observer's anxiety criteria, sedation scores, systolic and diastolic blood pressure (p<0.05). Heart rate was higher in the midazolam group but this was not statistically significant. There was no statistical significant difference in platelet aggregation profile in the two groups.
Findings of the study suggest midazolam is a good anxiolytic for pre-medication and its effect on platelet aggregation profile needs to be further evaluated.
手术与焦虑增加有关，这已得到充分证明，而焦虑会对患者的预后产生不利影响。本研究旨在通过临床和血小板聚集情况评估咪达唑仑在麻醉前用药中的抗焦虑作用。
60例年龄在35至60岁之间、接受择期腹部子宫切除术的美国麻醉医师协会（ASA）I级和II级女性患者被随机分为两组，每组人数相等。第一组接受安慰剂作为术前用药，而第二组在术前1小时接受0.15mg/kg的咪达唑仑作为术前用药。在术前用药前及用药后1小时，对她们进行焦虑视觉模拟量表（VAS）、观察者焦虑标准、镇静评分、血压、心率和血小板聚集情况的监测。
在焦虑VAS、观察者焦虑标准、镇静评分、收缩压和舒张压方面存在统计学显著差异（p<0.05）。咪达唑仑组的心率较高，但无统计学意义。两组的血小板聚集情况无统计学显著差异。
研究结果表明，咪达唑仑是一种良好的术前抗焦虑药物，其对血小板聚集情况的影响有待进一步评估。
