A组链球菌致热外毒素对清除功能的改变及其与抗体应答抑制的关系。
Alteration of clearance function by group A streptococcal pyrogenic exotoxin and its relation to suppression of the antibody response.
作者信息
Cunningham C M, Watson D W
出版信息
Infect Immun. 1978 Jan;19(1):51-7. doi: 10.1128/iai.19.1.51-57.1978.
Abstract
The effect of purified group A streptococcal pyrogenic exotoxin (SPE) type A on the processing of and antibody response to sheep erythrocytes (SRBC) was studied in BALB/cWat mice. The rate of clearance of 51Cr-labeled SRBC from the bloodstream was decreased 3 or 24 h following a single intravenous injection of 1 or 10 microgram of SPE. Delayed uptake of label was observed in both the livers and spleens of SPE-treated mice, suggesting an inhibitory effect of the toxin on phagocytic cells of the reticuloendothelial system. Three daily intravenous injections of 0.1 or 1 microgram of purified SPE type A suppressed the early immunoglobulin response to SRBC. The role of altered macrophage function in producing the immunosuppression was tested in macrophage transfer experiments. SPE treatment suppressed the antibody response to SRBC transferred by normal macrophages, indicating that the immunosuppressive effect of the toxin was not due solely to altered antigen processing by macrophages.
摘要
在BALB/cWat小鼠中研究了纯化的A组链球菌致热外毒素（SPE）A对绵羊红细胞（SRBC）处理及抗体反应的影响。单次静脉注射1或10微克SPE后3或24小时，51Cr标记的SRBC从血流中的清除率降低。在接受SPE处理的小鼠的肝脏和脾脏中均观察到标记摄取延迟，提示该毒素对网状内皮系统的吞噬细胞有抑制作用。每日静脉注射3次0.1或1微克纯化的A组SPE可抑制对SRBC的早期免疫球蛋白反应。在巨噬细胞转移实验中测试了巨噬细胞功能改变在产生免疫抑制中的作用。SPE处理抑制了正常巨噬细胞转移的SRBC的抗体反应，表明该毒素的免疫抑制作用并非仅由于巨噬细胞对抗原处理的改变。
相似文献
1
Alteration of clearance function by group A streptococcal pyrogenic exotoxin and its relation to suppression of the antibody response.A组链球菌致热外毒素对清除功能的改变及其与抗体应答抑制的关系。
Infect Immun. 1978 Jan;19(1):51-7. doi: 10.1128/iai.19.1.51-57.1978.
2
Suppression of antibody response by group A streptococcal pyrogenic exotoxin and characterization of the cells involved.A组链球菌致热外毒素对抗体反应的抑制作用及相关细胞的特性研究
Infect Immun. 1978 Feb;19(2):470-6. doi: 10.1128/iai.19.2.470-476.1978.
3
Deregulation of mouse antibody-forming cells in vivo in cell culture by streptococcal pyrogenic exotoxin.用链球菌致热外毒素在细胞培养中对体内小鼠抗体形成细胞进行去调节。
Infect Immun. 1975 Feb;11(2):265-72. doi: 10.1128/iai.11.2.265-272.1975.
4
[Effect of staphylococcal exotoxin on immune response to thymus-dependent and thymus-independent antigens].[葡萄球菌外毒素对胸腺依赖性和非胸腺依赖性抗原免疫反应的影响]
Zh Mikrobiol Epidemiol Immunobiol. 1980 Aug(8):112-3.
5
Host-parasite relationships among group A streptococci. IV. Suppression of antibody response by streptococcal pyrogenic exotoxin.A组链球菌的宿主-寄生虫关系。IV. 链球菌致热外毒素对抗体反应的抑制作用。
J Bacteriol. 1968 Jan;95(1):14-21. doi: 10.1128/jb.95.1.14-21.1968.
6
Activation of murine T cells by streptococcal pyrogenic exotoxin type A. Requirement for MHC class II molecules on accessory cells and identification of V beta elements in T cell receptor of toxin-reactive T cells.A 型链球菌致热外毒素对小鼠 T 细胞的激活作用。辅助细胞上 MHC Ⅱ类分子的需求以及毒素反应性 T 细胞 T 细胞受体中 Vβ元件的鉴定。
J Immunol. 1990 Nov 15;145(10):3170-6.
7
Acute inflammatory response to sheep red blood cell challenge in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): phenotypic and functional analysis of peritoneal exudate cells.2,3,7,8-四氯二苯并对二恶英（TCDD）处理的小鼠对绵羊红细胞攻击的急性炎症反应：腹腔渗出细胞的表型和功能分析
Toxicol Appl Pharmacol. 1993 Apr;119(2):248-57. doi: 10.1006/taap.1993.1066.
8
Influence of deoxyspergualin on mononuclear phagocytic system in mice.去氧精胍菌素对小鼠单核吞噬细胞系统的影响。
Life Sci. 1996;58(10):PL 171-5. doi: 10.1016/0024-3205(96)00022-7.
9
Transfer of group A streptococcal pyrogenic exotoxin production to nontoxigenic strains of lysogenic conversion.A组链球菌致热外毒素产生向溶原性转化的非产毒株的转移。
Infect Immun. 1980 Apr;28(1):254-7. doi: 10.1128/iai.28.1.254-257.1980.
10
Inhibition of ribonucleic acid synthesis by group A streptococcal pyrogenic exotoxin.A组链球菌致热外毒素对核糖核酸合成的抑制作用
Infect Immun. 1980 Feb;27(2):542-8. doi: 10.1128/iai.27.2.542-548.1980.
引用本文的文献
1
Activation of murine T-suppressor lymphocytes by group A streptococcal and staphylococcal pyurogenic exotoxins.A组链球菌和葡萄球菌致热外毒素对小鼠抑制性T淋巴细胞的激活作用。
Infect Immun. 1980 Jun;28(3):876-80. doi: 10.1128/iai.28.3.876-880.1980.
2
The gene for type A streptococcal exotoxin (erythrogenic toxin) is located in bacteriophage T12.A 型链球菌外毒素（致热外毒素）基因位于噬菌体 T12 中。
Infect Immun. 1984 Nov;46(2):531-6. doi: 10.1128/iai.46.2.531-536.1984.
3
Group A streptococcal phage T12 carries the structural gene for pyrogenic exotoxin type A.A组链球菌噬菌体T12携带A型致热外毒素的结构基因。
Mol Gen Genet. 1984;194(1-2):52-6. doi: 10.1007/BF00383496.
4
A physical map of the group A streptococcal pyrogenic exotoxin bacteriophage T12 genome.A群链球菌致热外毒素噬菌体T12基因组的物理图谱。
Mol Gen Genet. 1983;189(2):251-5. doi: 10.1007/BF00337813.
5
Inhibition of ribonucleic acid synthesis by group A streptococcal pyrogenic exotoxin.A组链球菌致热外毒素对核糖核酸合成的抑制作用
Infect Immun. 1980 Feb;27(2):542-8. doi: 10.1128/iai.27.2.542-548.1980.
6
Physiology of the potentiation of lethal endotoxin shock by streptococcal pyrogenic exotoxin in rabbits.链球菌致热外毒素对兔致死性内毒素休克的增强作用的生理学研究。
Infect Immun. 1987 Oct;55(10):2456-60. doi: 10.1128/iai.55.10.2456-2460.1987.
7
Molecular epidemiologic analysis of the type A streptococcal exotoxin (erythrogenic toxin) gene (speA) in clinical Streptococcus pyogenes strains.临床化脓性链球菌菌株中A群链球菌外毒素（致热外毒素）基因（speA）的分子流行病学分析
Infect Immun. 1989 Dec;57(12):3715-9. doi: 10.1128/iai.57.12.3715-3719.1989.
8
Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins.对皮下注射中毒性休克综合征毒素的家兔进行液体补充保护。
Infect Immun. 1991 Mar;59(3):879-84. doi: 10.1128/iai.59.3.879-884.1991.
9
Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci.A组链球菌临床分离株中致热外毒素B和C基因（speB和speC）的频率。
Infect Immun. 1991 Jan;59(1):211-5. doi: 10.1128/iai.59.1.211-215.1991.
10
Nonspecific T-lymphocyte mitogenesis by pyrogenic exotoxins from group A streptococci and Staphylococcus aureus.A组链球菌和金黄色葡萄球菌产生的致热外毒素引起的非特异性T淋巴细胞有丝分裂。
Infect Immun. 1979 Sep;25(3):1075-7. doi: 10.1128/iai.25.3.1075-1077.1979.
本文引用的文献
1
HOST-PARASITE RELATIONSHIPS AMONG GROUP A STREPTOCOCCI. 3. DEPRESSION OF RETICULOENDOTHELIAL FUNCTION BY STREPTOCOCCAL PYROGENIC EXOTOXINS.A组链球菌的宿主-寄生虫关系。3. 链球菌致热外毒素对网状内皮系统功能的抑制作用
J Bacteriol. 1965 Jan;89(1):154-8. doi: 10.1128/jb.89.1.154-158.1965.
2
RETICULOENDOTHELIAL FUNCTION AND THE IMMUNE RESPONSE.网状内皮系统功能与免疫反应
Science. 1963 Nov 22;142(3595):1078-80. doi: 10.1126/science.142.3595.1078.
3
Host-parasite factors in group A streptococcal infections. Pyrogenic and other effects of immunologic distinct exotoxins related to scarlet fever toxins.A组链球菌感染中的宿主-寄生虫因素。与猩红热毒素相关的免疫特性外毒素的致热及其他作用。
J Exp Med. 1960 Feb 1;111(2):255-84. doi: 10.1084/jem.111.2.255.
4
Phagocytosis of foreign red blood cells by the reticulo-endothelial system.网状内皮系统对外来红细胞的吞噬作用。
Am J Physiol. 1957 Jun;189(3):520-6. doi: 10.1152/ajplegacy.1957.189.3.520.
5
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
6
The effect of RES blockade on cellular antibody formation to sheep erythrocytes.RES阻断对针对绵羊红细胞的细胞抗体形成的影响。
Proc Soc Exp Biol Med. 1968 May;128(1):274-8. doi: 10.3181/00379727-128-32996.
7
Cytochemical identification of monocytes and granulocytes.单核细胞和粒细胞的细胞化学鉴定。
Am J Clin Pathol. 1971 Mar;55(3):283-90. doi: 10.1093/ajcp/55.3.283.
8
Tissue localization studies in evaluating the functional role of the RES.评估网状内皮系统功能作用的组织定位研究
J Reticuloendothel Soc. 1970 Mar;7(3):366-74.
9
10
A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock.一种纯化的A组链球菌致热外毒素。其理化和生物学特性，包括对内毒素致死性休克易感性的增强。
J Exp Med. 1970 Mar 1;131(3):611-22. doi: 10.1084/jem.131.3.611.
Zotero 插件