Cunningham C M, Watson D W
Infect Immun. 1978 Jan;19(1):51-7. doi: 10.1128/iai.19.1.51-57.1978.
The effect of purified group A streptococcal pyrogenic exotoxin (SPE) type A on the processing of and antibody response to sheep erythrocytes (SRBC) was studied in BALB/cWat mice. The rate of clearance of 51Cr-labeled SRBC from the bloodstream was decreased 3 or 24 h following a single intravenous injection of 1 or 10 microgram of SPE. Delayed uptake of label was observed in both the livers and spleens of SPE-treated mice, suggesting an inhibitory effect of the toxin on phagocytic cells of the reticuloendothelial system. Three daily intravenous injections of 0.1 or 1 microgram of purified SPE type A suppressed the early immunoglobulin response to SRBC. The role of altered macrophage function in producing the immunosuppression was tested in macrophage transfer experiments. SPE treatment suppressed the antibody response to SRBC transferred by normal macrophages, indicating that the immunosuppressive effect of the toxin was not due solely to altered antigen processing by macrophages.
在BALB/cWat小鼠中研究了纯化的A组链球菌致热外毒素（SPE）A对绵羊红细胞（SRBC）处理及抗体反应的影响。单次静脉注射1或10微克SPE后3或24小时，51Cr标记的SRBC从血流中的清除率降低。在接受SPE处理的小鼠的肝脏和脾脏中均观察到标记摄取延迟，提示该毒素对网状内皮系统的吞噬细胞有抑制作用。每日静脉注射3次0.1或1微克纯化的A组SPE可抑制对SRBC的早期免疫球蛋白反应。在巨噬细胞转移实验中测试了巨噬细胞功能改变在产生免疫抑制中的作用。SPE处理抑制了正常巨噬细胞转移的SRBC的抗体反应，表明该毒素的免疫抑制作用并非仅由于巨噬细胞对抗原处理的改变。
