Department of Pediatrics, Division of Pediatric Infectious Diseases, Monroe Carell Jr, Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA.
Expert Rev Respir Med. 2011 Jun;5(3):329-32. doi: 10.1586/ers.11.33.
In a recently performed case-control study, characteristics of the airway microbiota in suboptimally controlled adult asthmatics were compared with those of healthy, nonasthmatic adult subjects. Bacterial burden was significantly greater in asthmatic subjects. Further, increased airway microbiota variability and diversity were correlated with increased bronchial hyper-responsiveness. Although several limitations are present, this study provides an intriguing initial insight into the possible relationship between the airway microbiota and asthma pathogenesis.
在最近进行的一项病例对照研究中，比较了未得到充分控制的成年哮喘患者和健康非哮喘成年受试者的气道微生物组特征。哮喘患者的细菌负荷明显更高。此外，气道微生物组的变异性和多样性增加与支气管高反应性增加相关。尽管存在一些局限性，但这项研究为气道微生物组与哮喘发病机制之间可能存在的关系提供了一个有趣的初步见解。
