Department of Biostatistics, 677 Huntington Avenue, Harvard School of Public Health, Boston, MA 02115, USA.
Genome Biol. 2011 Jun 24;12(6):R60. doi: 10.1186/gb-2011-12-6-r60.
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.
本研究通过类别比较、生物一致性检验和效应量估计，描述并验证了一种新的宏基因组生物标志物发现方法。该方法解决了寻找能够始终如一地解释两个或更多微生物群落之间差异的生物、基因或途径的难题，这是宏基因组学研究的核心问题。我们在多个微生物组上对该方法进行了广泛验证，并在 http://huttenhower.sph.harvard.edu/lefse/ 提供了该方法的便捷在线接口。
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