Department of Pediatrics, Chi Mei Medical Center, Yong Kang Campus, Tainan, Taiwan.
Pediatr Neonatol. 2011 Jun;52(3):122-9. doi: 10.1016/j.pedneo.2011.03.008. Epub 2011 Apr 13.
Evidence continues to mount that adverse experiences early in life have an impact on brain functions. Early life stress can program the development of the hypothalamic-pituitary-adrenal axis and cause alterations of neurochemistry and signaling pathways involved in regulating neuroplasticity, with resultant neurobehavioral changes. Early life experiences and genetic factors appear to interact in determining the individual vulnerability to mental health disorders. We reviewed the effects of early life stress on neuroendocrine regulation and the relevance to neurobehavioral development.
越来越多的证据表明，生命早期的不良经历会对大脑功能产生影响。早期生活压力可以影响下丘脑-垂体-肾上腺轴的发育，并导致调节神经可塑性的神经化学和信号通路的改变，从而导致神经行为的变化。早期生活经历和遗传因素似乎在决定个体对心理健康障碍的易感性方面相互作用。我们综述了早期生活压力对神经内分泌调节的影响及其与神经行为发育的相关性。
