UCLA Brain Injury Research Center, University of California at Los Angeles, Los Angeles, CA, USA.
PM R. 2011 Jun;3(6 Suppl 1):S64-72. doi: 10.1016/j.pmrj.2011.02.008.
This article describes the effects of exercise on neural plasticity after traumatic brain injury (TBI). There is strong evidence that indicates that exercise has neuroprotective effects by activating specific neuronal circuits and increasing molecules that enhance synaptic plasticity. Findings obtained from experimental models of TBI are discussed to support the use of exercise as a rehabilitative tool. These studies indicate that injury characteristics are likely to influence the time window for therapeutic exercise. Results of human and animal studies suggest that premature postconcussive exercise may be deleterious by exacerbating postconcussive symptomatology and disrupting restorative processes. A better understanding of the mechanisms that influence exercise after TBI will contribute to improving guidelines for the return to exercise activities and to the successful use of exercise as a therapeutic tool.
本文描述了运动对创伤性脑损伤（TBI）后神经可塑性的影响。有强有力的证据表明，运动通过激活特定的神经元回路和增加增强突触可塑性的分子，具有神经保护作用。讨论了 TBI 的实验模型中获得的研究结果，以支持将运动作为康复工具的使用。这些研究表明，损伤特征可能会影响治疗性运动的时间窗。人类和动物研究的结果表明，过早的脑震荡后运动可能通过加重脑震荡后的症状和破坏恢复过程而产生有害影响。更好地了解影响 TBI 后运动的机制将有助于改进关于恢复运动活动的指南，并成功地将运动作为一种治疗工具使用。
