Sports Medicine, The Ohio State University, Columbus, OH 43221, USA.
PM R. 2011 Jun;3(6 Suppl 1):S78-81. doi: 10.1016/j.pmrj.2011.04.003.
Prolotherapy is a technique that involves the injection of an irritant, usually a hyperosmolar dextrose solution, typically in the treatment of chronic painful musculoskeletal conditions. Despite its long history and widespread use as a form of complementary therapy, there still are disparities over its optimal indications and injection preparations. There are, however, numerous studies available regarding the use and efficacy of prolotherapy for various musculoskeletal conditions. The most frequently published indication is in the treatment of chronic low back pain, but there are recent studies that examined its use in the management of refractory tendinopathies as well as osteoarthritis. There is growing evidence to suggest that prolotherapy may be helpful in treating chronic low back pain when coupled with adjunctive therapies, such as spinal manipulation or corticosteroid injections. There is also evidence to suggest that prolotherapy is effective in treating refractory tendinopathies, particularly for lateral epicondylosis and Achilles tendinopathy. Additional larger, randomized controlled trials are needed to make specific recommendations regarding ideal protocols and indications. There is emerging evidence for the use of prolotherapy as a treatment option for osteoarthritis; however, further studies are needed to conclusively demonstrate its efficacy. Overall, prolotherapy remains a promising option for the treatment of painful musculoskeletal conditions, particularly when other standard treatments have proved ineffective.
增生疗法是一种涉及注射刺激性物质的技术，通常是高渗葡萄糖溶液，主要用于治疗慢性疼痛性肌肉骨骼疾病。尽管它有着悠久的历史和广泛的应用作为一种补充疗法，但对于其最佳适应症和注射制剂仍存在差异。然而，有许多关于增生疗法治疗各种肌肉骨骼疾病的使用和疗效的研究。最常发表的适应症是治疗慢性腰痛，但最近有研究检查了其在治疗难治性肌腱病和骨关节炎中的应用。越来越多的证据表明，当与辅助治疗（如脊柱推拿或皮质类固醇注射）结合使用时，增生疗法可能有助于治疗慢性腰痛。也有证据表明，增生疗法对治疗难治性肌腱病有效，特别是对外侧肱骨上髁炎和跟腱病。需要更大规模的随机对照试验来制定关于理想方案和适应症的具体建议。有越来越多的证据表明，增生疗法是治疗骨关节炎的一种治疗选择;然而，还需要进一步的研究来明确证明其疗效。总的来说，增生疗法仍然是治疗疼痛性肌肉骨骼疾病的一种很有前途的选择，特别是当其他标准治疗方法已被证明无效时。
