Klinik und Poliklinik für Innere Medizin B, Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Friedrich-Löffler Str. 23 a, 17487 Greifswald, Germany.
Atherosclerosis. 2011 Nov;219(1):280-4. doi: 10.1016/j.atherosclerosis.2011.05.038. Epub 2011 Jun 12.
Low serum magnesium (Mg(++)) levels are associated with future development of left ventricular hypertrophy independently of common cardiovascular risk factors, as recently demonstrated in the five-year follow-up of the population-based Study of Health in Pomerania (SHIP). As left ventricular hypertrophy has significant prognostic implications, we hypothesized that serum Mg(++) levels are associated with cardiovascular mortality.
All-cause mortality and cardiovascular mortality were analyzed in relationship to serum Mg(++) concentrations at baseline by Cox proportional hazard model in SHIP (n=4203, exclusion of subjects with Mg(++) supplementation). The median duration of mortality follow-up was 10.1 years (25th percentile: 9.4 years, 75th percentile: 10.8 years; 38,075 person-years). During the follow-up, 417 deaths occurred. Mortality in subjects with Mg(++)≤0.73 mmol/l was significantly higher for all-cause deaths (10.95 death per 1000 person years), and cardiovascular deaths (3.44 deaths per 1000 person years) in comparison to higher Mg(++) concentrations (1.45 deaths from all-cause per 1000 person years, 1.53 deaths from cardiovascular cause per 1000 person years). This association remained statistically significant after adjustment for multiple cardiovascular risk factors, including arterial hypertension, and antihypertensive therapy including diuretics (log-rank-test p=0.0001 for all-cause mortality, and p=0.0174 for cardiovascular mortality).
Low serum Mg(++) levels are associated with higher all-cause mortality and cardiovascular mortality. This corresponds well with recent findings that hypomagnesemia is associated with the increase of left ventricular mass over the following years.
最近在基于人群的什未林健康研究（SHIP）的五年随访中发现，低血清镁（Mg++）水平与常见心血管危险因素无关，与左心室肥厚的未来发展有关。由于左心室肥厚具有重要的预后意义，我们假设血清 Mg++水平与心血管死亡率有关。
通过 Cox 比例风险模型，在 SHIP 中分析了全因死亡率和心血管死亡率与基线时血清 Mg++浓度的关系（n=4203，排除了 Mg++补充剂的受试者）。死亡率随访的中位时间为 10.1 年（25%分位数：9.4 年，75%分位数：10.8 年；38075 人年）。在随访期间，有 417 人死亡。与较高的 Mg++浓度相比，Mg++≤0.73mmol/l 的受试者全因死亡（每 1000 人年 10.95 例死亡）和心血管死亡（每 1000 人年 3.44 例死亡）的死亡率明显更高。调整包括动脉高血压在内的多种心血管危险因素后，这种相关性仍然具有统计学意义，以及包括利尿剂在内的抗高血压治疗（全因死亡率的对数秩检验 p=0.0001，心血管死亡率的 p=0.0174）。
低血清 Mg++水平与全因死亡率和心血管死亡率升高有关。这与最近的发现相符，即低镁血症与随后几年左心室质量的增加有关。
