Division of Infection and Immunity, Department of Immunology, University College London, London W1T 4JF, United Kingdom.
Curr Opin Immunol. 2011 Aug;23(4):525-31. doi: 10.1016/j.coi.2011.05.008. Epub 2011 Jun 22.
A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.
随着年龄的增长，老年人对皮肤感染和恶性肿瘤的易感性显著增加，表明皮肤免疫随年龄增长而受损。在这篇综述中，我们将重点介绍对皮肤免疫功能与年龄相关变化的理解方面的最新进展，特别强调参与固有和适应性免疫的细胞之间相互作用的改变如何导致皮肤抗原特异性 T 细胞免疫监视能力下降。
