Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Trends Endocrinol Metab. 2011 Sep;22(9):374-81. doi: 10.1016/j.tem.2011.05.002. Epub 2011 Jun 22.
The global obesity epidemic is associated with a series of health-threatening diseases including type 2 diabetes. Accumulating evidence suggest that the physiology and homeostasis of the endoplasmic reticulum (ER) is intimately involved in the underlying mechanisms linking obesity and diabetes. Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Focusing on the IRE1α-XBP1 pathway, we review recent advances in our understanding of the role of UPR in obesity and obesity-associated metabolic disorders.
全球肥胖症流行与一系列威胁健康的疾病相关，包括 2 型糖尿病。越来越多的证据表明，内质网（ER）的生理学和内稳态与肥胖和糖尿病之间的潜在机制密切相关。具体而言，最近的研究表明，需要肌醇的酶 1α（IRE1α）/X 盒结合蛋白 1（XBP1）途径，即未折叠蛋白反应（UPR）中最保守的分支，在葡萄糖和脂质代谢以及胰岛素功能中起着关键作用。本文聚焦于 IRE1α-XBP1 途径，综述了我们对 UPR 在肥胖和肥胖相关代谢紊乱中的作用的最新认识。
