Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.
Cytokine Growth Factor Rev. 2011 Jun;22(3):141-7. doi: 10.1016/j.cytogfr.2011.05.002. Epub 2011 Jun 23.
MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous miR-155 has been implicated in the pathogenesis of human cancers. Recently, aberrant expression of miR-155 was observed in many autoimmune conditions, including rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). Moreover, functional analysis demonstrated that miR-155 has powerful regulatory potential in a wide variety of immune cells through targeting specific mRNAs. Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity.
微小 RNA（miRNA）是一类主要的基因表达调控因子，与大多数生物功能有关。miR-155 编码在一个被称为 B 细胞整合簇（Bic）基因的区域内，最初被鉴定为禽类白血病病毒的频繁整合位点。内源性 miR-155 的失调与人类癌症的发病机制有关。最近，miR-155 的异常表达在许多自身免疫性疾病中观察到，包括类风湿关节炎（RA）、多发性硬化症（MS）和系统性红斑狼疮（SLE）。此外，功能分析表明，miR-155 通过靶向特定的 mRNA，在多种免疫细胞中具有强大的调节潜力。由于致病免疫细胞在人类自身免疫性疾病的发病机制中起着关键作用，miR-155 可能是一个多功能的治疗靶点。本文将讨论目前对 miR-155 在自身免疫中的作用的认识。
