Equipe Avenir INSERM Bettencourt Schueller, F-91191 Gif-sur-Yvette, France.
Neuroimage. 2011 Sep 1;58(1):60-8. doi: 10.1016/j.neuroimage.2011.06.019. Epub 2011 Jun 16.
Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current MRI approaches are still limited to localize brainstem and basal ganglia nuclei accurately. By combining ultra-high resolution structural MRI and contrast-enhanced MRI using iron oxide nanoparticles at high field (3T and 7T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.
皮质下核越来越多地成为深部脑刺激（DBS）和基因转移的目标，以治疗神经和精神疾病。为了使患者获得成功的治疗效果，将 DBS 电极或病毒载体准确地放置在目标核内是至关重要的。然而，目前的 MRI 方法仍然局限于准确定位脑干和基底神经节核。通过在高磁场（3T 和 7T）下使用氧化铁纳米颗粒结合超高分辨率结构 MRI 和对比增强 MRI，我们可以精确地定位皮质下核，特别是在猕猴中的丘脑底核，并通过颅内电生理图谱验证这一位置。目前的数据为临床应用铺平了道路。
