Pereira J H, Cowley S A, Gschmeissner S E, Bowden R E, Turk J L
Department of Anatomy, Royal College of Surgeons, London, England.
J Bone Joint Surg Br. 1990 Sep;72(5):874-80. doi: 10.1302/0301-620X.72B5.2170419.
About 20% of patients with leprosy develop localised granulomatous lesions in peripheral nerves. We report experiments in guinea-pigs in which freeze-thawed autogenous muscle grafts were used for the treatment of such mycobacterial granulomas. Granulomas were induced in guinea-pig tibial nerves and the animals were left for 7 to 100 days in order to assess maximal damage. The local area of nerve damage was then excised and the gap filled with denatured muscle grafts. Clinical assessment after periods up to 150 days showed good sensory and motor recovery which correlated well with the histological findings. The muscle graft technique may be of value for the treatment of chronic nerve lesions in selected cases of leprosy.
约20%的麻风病患者会在外周神经出现局部肉芽肿性病变。我们报告了在豚鼠身上进行的实验，其中使用冻融自体肌肉移植来治疗此类分枝杆菌性肉芽肿。在豚鼠胫神经中诱导形成肉芽肿，让动物存活7至100天以评估最大损伤程度。然后切除神经损伤的局部区域，并用变性肌肉移植物填充间隙。长达150天的临床评估显示感觉和运动功能恢复良好，这与组织学结果密切相关。肌肉移植技术可能对某些麻风病病例的慢性神经病变治疗具有价值。
