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体外受精和胞浆内单精子注射妊娠胎盘中 H19/IGF2 ICR1 的 DNA 甲基化。

DNA methylation at H19/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection.

机构信息

Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Fertil Steril. 2011 Jun 30;95(8):2524-6.e1-3. doi: 10.1016/j.fertnstert.2011.05.047.

DOI:10.1016/j.fertnstert.2011.05.047
PMID:21704210
Abstract

DNA methylation at H19 ICR1 was investigated in the placenta from pregnancies conceived by in vitro fertilization, intracytoplasmic sperm injection, and from natural conception. Our results showed that there were no significant differences in mean methylation between all pregnancy groups; therefore, assisted reproductive technology may not affect proper imprinting of H19 and IGF2.

摘要

我们研究了体外受精、胞浆内单精子注射和自然受孕妊娠的胎盘样本中 H19 ICR1 的 DNA 甲基化。结果显示，所有妊娠组的平均甲基化水平无显著差异；因此，辅助生殖技术可能不会影响 H19 和 IGF2 的正常印迹。

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