Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Crit Rev Oncol Hematol. 2012 May;82(2):213-26. doi: 10.1016/j.critrevonc.2011.05.006. Epub 2011 Jun 25.
Pancreatic islet cell tumors are neuroendocrine tumors, which can produce hormones and can arise as part of multiple endocrine neoplasia type 1 or von-Hippel-Lindau-disease, two genetically well-defined hereditary cancer syndromes. Currently, technical innovation improves conventional and specific molecular imaging techniques. To organize the heterogeneous results described for the imaging of these tumors, we distinguished three indications (1) imaging of a patient with hormone hypersecretion, (2) search for a pancreatic primary in case of proven neuroendocrine cancer of unknown primary, and (3) screening of asymptomatic mutation carriers. We searched for publications on imaging of islet cell tumors between 1995 and January 2010 and defined a Level of Evidence (LOE) for the applicability of each technique. For each technique, data were analyzed in a Forest plot and arranged per imaging indication and tumor subtype. LOEs are weak for all imaging techniques. Analyses indicate a prominent role for endoscopic ultrasound for all three indications.
胰岛细胞瘤是神经内分泌肿瘤，可产生激素，并可能作为多发性内分泌肿瘤 1 型或 von-Hippel-Lindau 疾病的一部分发生，这两种疾病都是遗传明确的遗传性癌症综合征。目前，技术创新提高了常规和特定的分子成像技术。为了整理描述这些肿瘤的成像的异质结果，我们区分了三种适应症：（1）激素分泌过多患者的成像；（2）在已确诊的不明原发神经内分泌癌的情况下寻找胰腺原发灶；（3）无症状突变携带者的筛查。我们在 1995 年至 2010 年 1 月期间搜索了关于胰岛细胞瘤成像的出版物，并为每种技术的适用性定义了证据水平（LOE）。对于每种技术，我们在森林图中分析数据，并根据成像适应症和肿瘤亚型进行排列。LOE 对所有成像技术都较弱。分析表明，内镜超声在所有三种适应症中都具有突出作用。
