Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Alpert Medical School of Brown University, Box G-RIH, Providence, RI 02912, USA.
Sleep Med. 2011 Aug;12(7):685-92. doi: 10.1016/j.sleep.2011.01.016. Epub 2011 Jun 24.
We examined the effects of an advanced sleep/wake schedule and morning short wavelength (blue) light in 25 adults (mean age±SD=21.8±3 years; 13 women) with late sleep schedules and subclinical features of delayed sleep phase disorder (DSPD).
After a baseline week, participants kept individualized, fixed, advanced 7.5-h sleep schedules for 6days. Participants were randomly assigned to groups to receive "blue" (470nm, ∼225lux, n=12) or "dim" (<1lux, n=13) light for 1h after waking each day. Head-worn "Daysimeters" measured light exposure; actigraphs and sleep diaries confirmed schedule compliance. Salivary dim light melatonin onset (DLMO), self-reported sleep, and mood were examined with 2×2 ANOVA.
After 6days, both groups showed significant circadian phase advances, but morning blue light was not associated with larger phase shifts than dim-light exposure. The average DLMO advances (mean±SD) were 1.5±1.1h in the dim light group and 1.4±0.7h in the blue light group.
Adherence to a fixed advanced sleep/wake schedule resulted in significant circadian phase shifts in young adults with subclinical DSPD with or without morning blue light exposure. Light/dark exposures associated with fixed early sleep schedules are sufficient to advance circadian phase in young adults.
我们研究了在 25 名（平均年龄±标准差=21.8±3 岁；女性 13 名）晚睡、存在亚临床睡眠时相延迟障碍（DSPD）特征的成年人中，提前睡眠/觉醒时间表和早晨短波长（蓝光）光照的影响。
在基线周后，参与者保持个体化、固定的提前 7.5 小时睡眠时间表 6 天。参与者被随机分配到两组，每天醒来后接受“蓝光”（470nm，约 225lux，n=12）或“暗光”（<1lux，n=13）光照 1 小时。头戴式“Daysimeters”测量光照暴露；活动记录仪和睡眠日记确认了时间表的遵守情况。使用 2×2 ANOVA 检查唾液褪黑素初始时间（DLMO）、自我报告的睡眠和情绪。
经过 6 天，两组均显示出明显的昼夜相位提前，但早晨蓝光照射与更大的相位变化无关。在暗光组中，平均 DLMO 提前（平均值±标准差）为 1.5±1.1 小时，在蓝光组中为 1.4±0.7 小时。
对于存在亚临床 DSPD 的年轻成年人，固定的提前睡眠/觉醒时间表的遵守导致了明显的昼夜相位变化，无论是否在早晨接受蓝光照射。与固定的早期睡眠时间表相关的光照/黑暗暴露足以使年轻成年人的昼夜相位提前。
