Rea Mark S, Nagare Rohan, Bierman Andrew, Figueiro Mariana G
Light and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Neurosci. 2022 Sep 27;16:965525. doi: 10.3389/fnins.2022.965525. eCollection 2022.
Modeling how patterns of light and dark affect circadian phase is important clinically and organizationally (e.g., the military) because circadian disruption can compromise health and performance. Limit-cycle oscillator models in various forms have been used to characterize phase changes to a limited set of light interventions. We approached the analysis of the van der Pol oscillator-based model proposed by Kronauer and colleagues in 1999 and 2000 (Kronauer99) using a well-established framework from experimental psychology whereby the stimulus (S) acts on the organism (O) to produce a response (R). Within that framework, using four independent data sets utilizing calibrated personal light measurements, we conducted a serial analysis of the factors in the Kronauer99 model that could affect prediction accuracy characterized by changes in dim-light melatonin onset. Prediction uncertainty was slightly greater than 1 h for the new data sets using the original Kronauer99 model. The revised model described here reduced prediction uncertainty for these same data sets by roughly half.
模拟明暗模式如何影响昼夜节律相位在临床和组织层面（如军队）都很重要，因为昼夜节律紊乱会损害健康和表现。各种形式的极限环振荡器模型已被用于描述对有限一组光照干预的相位变化。我们采用实验心理学中一个成熟的框架来分析克朗瑙尔及其同事在1999年和2000年提出的基于范德波尔振荡器的模型（克朗瑙尔99模型），在该框架中，刺激（S）作用于生物体（O）以产生反应（R）。在该框架内，我们使用四个利用校准后的个人光照测量的独立数据集，对克朗瑙尔99模型中可能影响以暗光褪黑素开始时间变化为特征的预测准确性的因素进行了系列分析。使用原始的克朗瑙尔99模型时，新数据集的预测不确定性略大于1小时。此处描述的修订模型将这些相同数据集的预测不确定性降低了约一半。
