The Australian Mouse Brain Mapping Consortium, The University of Queensland, Queensland, Brisbane, Australia.
Neuroimage. 2011 Oct 1;58(3):732-40. doi: 10.1016/j.neuroimage.2011.06.025. Epub 2011 Jun 17.
The hippocampal formation plays an important role in cognition, spatial navigation, learning, and memory. High resolution magnetic resonance (MR) imaging makes it possible to study in vivo changes in the hippocampus over time and is useful for comparing hippocampal volume and structure in wild type and mutant mice. Such comparisons demand a reliable way to segment the hippocampal formation. We have developed a method for the systematic segmentation of the hippocampal formation using the perfusion-fixed C57BL/6 mouse brain for application in longitudinal and comparative studies. Our aim was to develop a guide for segmenting over 40 structures in an adult mouse brain using 30 μm isotropic resolution images acquired with a 16.4 T MR imaging system and combined using super-resolution reconstruction.
海马结构在认知、空间导航、学习和记忆中发挥着重要作用。高分辨率磁共振（MR）成像使得研究海马体随时间的变化成为可能，并且有助于比较野生型和突变型小鼠的海马体体积和结构。这种比较需要一种可靠的方法来分割海马结构。我们开发了一种使用灌注固定的 C57BL/6 鼠脑进行系统分割海马结构的方法，用于纵向和比较研究。我们的目标是使用 16.4 T MR 成像系统获取具有 30μm 各向同性分辨率的图像，并结合超分辨率重建，为分割成年鼠脑中的 40 多种结构开发一个指南。
