Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.
J Magn Reson Imaging. 2011 Mar;33(3):565-72. doi: 10.1002/jmri.22473.
To compare the hippocampal volumes in patients with bipolar disorder (BD) and healthy controls, obtained by applying different segmentation methods (manual, Freesurfer [FS], and FSL).
The study included 27 patients with BD and 40 healthy controls. T1-weighted images in the sagittal plane were acquired on a 3 Tesla (T) MR scanner. Hippocampal volumetry was performed using one manual and two automated methods (FS and FSL). One-way repeated analysis of variance was applied to test the differences in hippocampal volumes using the three segmentation methods. To evaluate the agreement among the three tested volumetric segmentation methods the intraclass correlation coefficients (ICCs) were calculated.
Hippocampal volumes obtained from all methods were significantly different (P < 0.05) in BD patients after intracranial volume correction, indicating a reduction in volume, unless from the manual method of the left hippocampal volume. The ICCs of the hippocampal volume between the manual method and FS were 0.846 (right) and 0.859 (left), and between the manual method and FSL were 0.746 (right) and 0.654 (left).
Both manual and automatic segmentation methods detected reductions in the hippocampal volumes in BD patients. Automated segmentation methods are a robust and reproducible option for assessing hippocampal volume.
比较使用手动、Freesurfer（FS）和 FSL 等不同分割方法获得的双相情感障碍（BD）患者和健康对照组的海马体积。
该研究纳入了 27 例 BD 患者和 40 例健康对照组。在 3T MR 扫描仪上采集矢状面 T1 加权图像。使用一种手动和两种自动方法（FS 和 FSL）进行海马体积测量。采用单向重复方差分析比较三种分割方法的海马体积差异。为评估三种测试体积分割方法之间的一致性，计算了组内相关系数（ICCs）。
在进行颅内体积校正后，所有方法获得的 BD 患者的海马体积均有显著差异（P < 0.05），表明体积减小，除非来自左侧海马体的手动方法。手动方法与 FS 之间的海马体积 ICC 为 0.846（右侧）和 0.859（左侧），手动方法与 FSL 之间的 ICC 为 0.746（右侧）和 0.654（左侧）。
手动和自动分割方法均检测到 BD 患者的海马体积减小。自动分割方法是评估海马体积的可靠且可重复的选择。
