Department of Physiology, Faculty of Medicine, The Centre for the Study of Pain, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.
Semin Cell Dev Biol. 2011 Jul;22(5):521-9. doi: 10.1016/j.semcdb.2011.06.003. Epub 2011 Jun 17.
N-methyl-d-aspartate receptors (NMDA receptors) play critical roles in brain functions and diseases. The expression, trafficking, synaptic location and function of different NMDA receptor subtypes are not static, but regulated dynamically in a cell-specific and synapse-specific manner during physiological and pathological conditions. In this review, we will examine recent evidence on the post-translational modulation of NMDA receptors subunit, in particular GluN2B subunit, such as phosphorylation, palmitoylation, and ubiquitination. In parallel, we will overview the roles of these modifications of GluN2B-NMDA receptor subtype in physiological functions, such as learning and memory, and pathophysiological conditions, such as chronic pain, ischemia and neurodegenerative diseases.
N-甲基-D-天冬氨酸受体（NMDA 受体）在大脑功能和疾病中发挥着关键作用。不同 NMDA 受体亚基的表达、运输、突触位置和功能不是静态的，而是在生理和病理条件下以细胞特异性和突触特异性的方式进行动态调节的。在这篇综述中，我们将检查 NMDA 受体亚基，特别是 GluN2B 亚基，后翻译调节的最新证据，如磷酸化、棕榈酰化和泛素化。同时，我们将概述这些 GluN2B-NMDA 受体亚型修饰在生理功能（如学习和记忆）和病理生理条件（如慢性疼痛、缺血和神经退行性疾病）中的作用。
