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应激模拟:促肾上腺皮质激素和锌对肝脏及脾脏中微量元素的影响

Stress simulation: ACTH and zinc effect on trace metals in liver and spleen.

作者信息

Armario A, Flos R, Balasch J

出版信息

Rev Esp Fisiol. 1978 Dec;34(4):395-9.

PMID:217049
Abstract

Effect of ACTH and zinc acetate subcutaneous injection on the trace metals in liver and spleen was investigated in male Wistar rats. Iron, copper, zinc and manganese in liver, and iron, copper and zinc in spleen were analyzed by AAS method. The iron, copper and zinc levels in liver, and iron levels in spleen showed a significant decrease at 1-1 h 30 min after administration of 30 UI of ACTH but values returned to normality or showed slightly higher levels at 4 h 30 min-7 h 45 min. Zinc acetate injection only elicited an increase in liver and spleen zinc levels. Results are discussed in relation with results given in previous papers.

摘要

研究了促肾上腺皮质激素(ACTH)和皮下注射醋酸锌对雄性Wistar大鼠肝脏和脾脏中微量元素的影响。采用原子吸收光谱法(AAS法)分析了肝脏中的铁、铜、锌和锰,以及脾脏中的铁、铜和锌。给予30单位ACTH后1至1小时30分钟,肝脏中的铁、铜和锌水平以及脾脏中的铁水平显著下降,但在4小时30分钟至7小时45分钟时恢复正常或略有升高。仅注射醋酸锌会使肝脏和脾脏中的锌水平升高。结合先前论文中的结果对本研究结果进行了讨论。

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