University Hospital Mother/Child (Sainte Justine Hospital), Montréal, QC, Canada.
Epilepsy Behav. 2011 Aug;21(4):430-6. doi: 10.1016/j.yebeh.2011.05.009. Epub 2011 Jun 25.
Consequences of status epilepticus (SE) on psychomotor development and the specific impact of the convulsive event on emerging executive functions remain controversial. Infants treated for a single episode of SE, those treated for a single febrile seizure, and healthy infants were tested with respect to motor development, language, personal, and social skills and self-regulation. The children were divided into two age groups to investigate the impact of the convulsive event at different windows of brain maturation. We found that infants who had had SE were inferior to healthy controls on the development scales. Age differentiated SE impact on visuomotor development versus sociolinguistic development. Children who had been treated for SE had significantly more difficulties delaying a response to an attractive stimulus in one of the long-delay conditions. A single episode of SE can interfere with psychomotor and cognitive development in children without previous developmental delay, and it seems that the functions that are emerging at the time of insult are most vulnerable.
癫痫持续状态 (SE) 对精神运动发育的影响，以及惊厥事件对新兴执行功能的具体影响仍存在争议。对单次 SE 发作接受治疗的婴儿、单次热性惊厥发作接受治疗的婴儿和健康婴儿进行了运动发育、语言、个人和社会技能以及自我调节方面的测试。根据大脑成熟的不同窗口，将儿童分为两个年龄组，以研究惊厥事件的影响。我们发现，患有 SE 的婴儿在发育量表上的表现不如健康对照组。SE 对视觉运动发育与社会语言发育的影响因年龄而异。在一个长延迟条件下，曾接受 SE 治疗的儿童对有吸引力的刺激做出反应的延迟明显更困难。单次 SE 发作可干扰无先前发育迟缓的儿童的精神运动和认知发育，而且似乎在受影响时出现的功能最容易受到影响。
