Lehtinen R, Kuusilehto A, Nikkanen U M
Department of Oral Surgery, University of Turku, Finland.
J Oral Maxillofac Surg. 1990 Oct;48(10):1075-8. doi: 10.1016/0278-2391(90)90292-a.
Four holes drilled in rabbit tibia were filled with different commercial hydroxyapatite products. All particles caused a mild inflammatory reaction, which disappeared in 2 months. The line between the new and original bone was visible even after 6 months. No differences in healing pattern were discovered for the various products. When bone cavities are filled with hydroxyapatite particles, the shape of the particles does not seem to affect the healing process.
在兔胫骨上钻的四个孔中填充了不同的商用羟基磷灰石产品。所有颗粒均引起轻度炎症反应,该反应在2个月内消失。即使在6个月后,新骨与原骨之间的界限仍清晰可见。未发现不同产品在愈合模式上存在差异。当骨腔用羟基磷灰石颗粒填充时,颗粒的形状似乎不影响愈合过程。