Al Ruhaimi K A
Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Int J Oral Maxillofac Implants. 2001 Jan-Feb;16(1):105-14.
This paper investigated the osteogenic potential of 6 osteoconductive grafting materials derived from human, bovine, and synthetic sources: HTR, BOP, Biogran, Laddec, Dembone, and Osteograf. Twenty-eight New Zealand rabbits were used in this study. The active group consisted of 24 animals and the control group consisted of 4 animals. The median condyle of each tibia was drilled with a 5-mm-diameter bur to form 8 mm-deep cavities. A control group included 8 osseous cavities, with 1 hole in each tibia. These cavities were washed and left unfilled. In the active group, each grafting material filled 8 osseous cavities in 8 tibiae of different animals. Half of the active and control osseous cavities were investigated with decalcified hematoxylin and eosin-stained sections. The other half were studied with scanning electron microscopy. It was concluded that Laddec bovine bone granules possessed the best potential for an osteoconductive grafting material, followed by the bioglass crystals of Biogran and the hydroxyapatite particles of Osteograf, respectively. The least potential for rapid bone formation was demonstrated by the copolymers of HTR and BOP, and Dembone allograft bone particles did not reveal active bone healing.
本文研究了6种来源于人、牛和合成材料的骨传导性移植材料的成骨潜力：HTR、BOP、Biogran、Laddec、Dembone和Osteograf。本研究使用了28只新西兰兔。实验组由24只动物组成，对照组由4只动物组成。用直径5毫米的钻头在每只胫骨的髁中部钻出8毫米深的骨腔。对照组包括8个骨腔，每只胫骨上有1个孔。这些骨腔经冲洗后未填充。在实验组中，每种移植材料填充不同动物的8只胫骨中的8个骨腔。实验组和对照组的一半骨腔用脱钙苏木精和伊红染色切片进行研究。另一半用扫描电子显微镜进行研究。得出的结论是，Laddec牛骨颗粒作为骨传导性移植材料的潜力最佳，其次分别是Biogran的生物玻璃晶体和Osteograf的羟基磷灰石颗粒。HTR和BOP的共聚物显示出快速骨形成的潜力最小，同种异体移植骨颗粒Dembone未显示出活跃的骨愈合。
