Prudencio Almudena, Carbone Ashley L, Griffin Jeremy, Uhrich Kathryn E
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway NJ 08854-8087, USA.
Macromol Rapid Commun. 2009 Jul 1;30(13):1101-8. doi: 10.1002/marc.200900059. Epub 2009 May 11.
Antiseptics based on phenol and phenolic derivatives were chemically incorporated into polyanhydrides as pendant groups via ester linkages. Polyanhydrides with antiseptic loadings of 46-58 wt.-% were obtained with molecular weights ranging from 9 400-23 000. In general, polymers with the bulkier antiseptics were more difficult to polymerize and yielded lower molecular weights. All polyanhydrides were amorphous with glass transition temperatures ranging from 27-58 °C. Polymers were deemed noncytotoxic after culturing L929 mouse fibroblast cells in media containing the polymers at two concentrations (0.10 and 0.01 mg · mL(-1) ) over three days. In summary, mono-functional bioactives can be chemically incorporated into noncytotoxic polyanhydrides.
基于苯酚和酚类衍生物的防腐剂通过酯键作为侧基化学结合到聚酸酐中。获得了具有46 - 58 wt.-%防腐剂负载量的聚酸酐，其分子量范围为9400 - 23000。一般来说，含有体积较大防腐剂的聚合物更难聚合，且分子量较低。所有聚酸酐都是无定形的，玻璃化转变温度范围为27 - 58°C。在含有聚合物的两种浓度（0.10和0.01 mg·mL⁻¹）的培养基中培养L929小鼠成纤维细胞三天后，聚合物被认为无细胞毒性。总之，单官能生物活性物质可以化学结合到无细胞毒性的聚酸酐中。
