快速降解聚（酸酐 - 酯）的设计与合成
Design and Synthesis of Fast-Degrading Poly(anhydride-esters).
作者信息
Carbone Ashley L, Uhrich Kathryn E
机构信息
Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersy 08854-8087, USA.
出版信息
Macromol Rapid Commun. 2009 Jun 17;30(12):1021. doi: 10.1002/marc.200900029.
Abstract
Fast-degrading, salicylate-based poly(anhydride-esters) were designed to degrade and release the active component, salicylic acid (SA), within 1 week. The polymer degradation was enhanced by using shorter or oxygen-containing aliphatic chains. A copolymer of diglycolic acid was also made with a salicylate-based diacid for comparison of polymer properties, including SA release. Both methods resulted in polyanhydrides with molecular weights ranging from 14 500 to 27 800 Da and displayed glass transition temperatures near physiological conditions, namely 33-40 degrees C. the homo- and copolymers completely degraded within one week releasing the chemically incorporated SA.
摘要
快速降解的水杨酸基聚（酸酐 - 酯）被设计用于在1周内降解并释放活性成分水杨酸（SA）。通过使用较短的或含氧化合物的脂肪族链来增强聚合物的降解。还制备了一种由二乙醇酸与水杨酸基二酸组成的共聚物，用于比较聚合物的性能，包括SA的释放。两种方法都得到了分子量在14500至27800 Da之间的聚酸酐，并在接近生理条件下（即33 - 40摄氏度）显示出玻璃化转变温度。均聚物和共聚物在一周内完全降解，释放出化学结合的SA。
相似文献
1
Design and Synthesis of Fast-Degrading Poly(anhydride-esters).
Macromol Rapid Commun. 2009 Jun 17;30(12):1021. doi: 10.1002/marc.200900029.
2
Tunable drug release profiles from salicylate-based poly(anhydride-ester) matrices using small molecule admixtures.
J Bioact Compat Polym. 2012 Nov 1;27(6):540-549. doi: 10.1177/0883911512464605.
3
Synthesis and characterization of antiseptic-based poly(anhydride-esters).
Polym Bull (Berl). 2006 Jul 1;57(3):281-291. doi: 10.1007/s00289-006-0561-z.
4
Synthesis and Characterization of Salicylic Acid-Based Poly(Anhydride-Ester) Copolymers.
J Bioact Compat Polym. 2006 Mar;21(2):123-133. doi: 10.1177/0883911506062976.
5
Poly(ester-anhydrides) Derived from Esters of Hydroxy Acid and Cyclic Anhydrides.
Biomacromolecules. 2022 Aug 8;23(8):3417-3428. doi: 10.1021/acs.biomac.2c00542. Epub 2022 Jul 26.
6
Iodinated salicylate-based poly(anhydride-esters) as radiopaque biomaterials.
Biomacromolecules. 2008 Jun;9(6):1604-12. doi: 10.1021/bm8000759. Epub 2008 May 16.
7
Synthesis and cytotoxicity of salicylate-based poly(anhydride esters).
Biomacromolecules. 2005 Jan-Feb;6(1):359-67. doi: 10.1021/bm049544+.
8
Concurrent release of admixed antimicrobials and salicylic acid from salicylate-based poly(anhydride-esters).
J Biomed Mater Res A. 2009 Dec;91(3):671-8. doi: 10.1002/jbm.a.32288.
9
Biodegradation of poly(anhydride-esters) into non-steroidal anti-inflammatory drugs and their effect on Pseudomonas aeruginosa biofilms in vitro and on the foreign-body response in vivo.
Biomaterials. 2006 Oct;27(29):5039-48. doi: 10.1016/j.biomaterials.2006.05.034. Epub 2006 Jun 14.
10
Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride-esters).
Macromolecules. 2005;38(16):6895-6901. doi: 10.1021/ma048051u.
引用本文的文献
1
Polyanhydride Microcapsules Exhibiting a Sharp pH Transition at Physiological Conditions for Instantaneous Triggered Release.
Langmuir. 2023 Dec 12;39(49):18003-18010. doi: 10.1021/acs.langmuir.3c02708. Epub 2023 Nov 17.
2
Modulating lysosomal pH: a molecular and nanoscale materials design perspective.
J Life Sci (Westlake Village). 2020 Dec;2(4):25-37. doi: 10.36069/jols/20201204.
3
Poly(anhydride-ester) gemcitabine: Synthesis and particle engineering of a high payload hydrolysable polymeric drug for cancer therapy.
J Control Release. 2021 Feb 10;330:1178-1190. doi: 10.1016/j.jconrel.2020.11.025. Epub 2020 Nov 17.
4
Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma.
J Immunother Cancer. 2019 Mar 19;7(1):79. doi: 10.1186/s40425-019-0550-z.
5
Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials.
Macromol Biosci. 2016 Feb;16(2):214-22. doi: 10.1002/mabi.201500244. Epub 2015 Oct 1.
6
Salicylic Acid-Based Polymers for Guided Bone Regeneration Using Bone Morphogenetic Protein-2.
Tissue Eng Part A. 2015 Jul;21(13-14):2013-24. doi: 10.1089/ten.TEA.2014.0455. Epub 2015 Apr 29.
7
Synthesis and Characterization of a Poly(ethylene glycol)-Poly(simvastatin) Diblock Copolymer.
RSC Adv. 2014 Jan 1;4(102):58287-58298. doi: 10.1039/C4RA10310F.
8
Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.
Macromol Biosci. 2015 Mar;15(3):342-50. doi: 10.1002/mabi.201400238. Epub 2014 Oct 21.
9
Tunable drug release profiles from salicylate-based poly(anhydride-ester) matrices using small molecule admixtures.
J Bioact Compat Polym. 2012 Nov 1;27(6):540-549. doi: 10.1177/0883911512464605.
10
Formulation of salicylate-based poly(anhydride-ester) microspheres for short- and long-term salicylic acid delivery.
Polym Bull (Berl). 2013 Jan 1;70(1):343-351. doi: 10.1007/s00289-012-0839-2. Epub 2012 Sep 7.
本文引用的文献
1
Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride-esters).
Macromolecules. 2005;38(16):6895-6901. doi: 10.1021/ma048051u.
2
Synthesis and Characterization of Salicylic Acid-Based Poly(Anhydride-Ester) Copolymers.
J Bioact Compat Polym. 2006 Mar;21(2):123-133. doi: 10.1177/0883911506062976.
3
Comparison of salicylate-based poly(anhydride-esters) formed via melt-condensation versus solution polymerization.
J Biomater Sci Polym Ed. 2008;19(10):1295-306. doi: 10.1163/156856208786052362.
4
Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing.
Int J Pharm. 2008 Nov 19;364(1):87-93. doi: 10.1016/j.ijpharm.2008.07.033. Epub 2008 Aug 15.
5
Novel bioabsorbable salicylate-based polymer as a drug-eluting stent coating.
Catheter Cardiovasc Interv. 2008 Aug 1;72(2):186-94. doi: 10.1002/ccd.21607.
6
Iodinated salicylate-based poly(anhydride-esters) as radiopaque biomaterials.
Biomacromolecules. 2008 Jun;9(6):1604-12. doi: 10.1021/bm8000759. Epub 2008 May 16.
7
Salicylic acid-based poly(anhydride esters) for control of biofilm formation in Salmonella enterica serovar Typhimurium.
Lett Appl Microbiol. 2008 May;46(5):593-9. doi: 10.1111/j.1472-765X.2008.02356.x. Epub 2008 Mar 26.
8
Non-steroidal anti-inflammatory drug (NSAID)-derived poly(anhydride-esters) in bone and periodontal regeneration.
Curr Drug Deliv. 2007 Jul;4(3):233-9. doi: 10.2174/156720107781023866.
9
Characterization and in vitro degradation of salicylate-derived poly(anhydride-ester microspheres).
J Microencapsul. 2006 Sep;23(6):643-53. doi: 10.1080/02652040600776481.
10
Recent developments in biodegradable synthetic polymers.
Biotechnol Annu Rev. 2006;12:301-47. doi: 10.1016/S1387-2656(06)12009-8.
Zotero 插件