Carbone Ashley L, Uhrich Kathryn E
Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersy 08854-8087, USA.
Macromol Rapid Commun. 2009 Jun 17;30(12):1021. doi: 10.1002/marc.200900029.
Fast-degrading, salicylate-based poly(anhydride-esters) were designed to degrade and release the active component, salicylic acid (SA), within 1 week. The polymer degradation was enhanced by using shorter or oxygen-containing aliphatic chains. A copolymer of diglycolic acid was also made with a salicylate-based diacid for comparison of polymer properties, including SA release. Both methods resulted in polyanhydrides with molecular weights ranging from 14 500 to 27 800 Da and displayed glass transition temperatures near physiological conditions, namely 33-40 degrees C. the homo- and copolymers completely degraded within one week releasing the chemically incorporated SA.
快速降解的水杨酸基聚（酸酐 - 酯）被设计用于在1周内降解并释放活性成分水杨酸（SA）。通过使用较短的或含氧化合物的脂肪族链来增强聚合物的降解。还制备了一种由二乙醇酸与水杨酸基二酸组成的共聚物，用于比较聚合物的性能，包括SA的释放。两种方法都得到了分子量在14500至27800 Da之间的聚酸酐，并在接近生理条件下（即33 - 40摄氏度）显示出玻璃化转变温度。均聚物和共聚物在一周内完全降解，释放出化学结合的SA。
