Brewster Jay L, Beason K Beth, Eckdahl Todd T, Evans Irene M
‡ Natural Science Division, Pepperdine University, Malibu, CA 90263; § The Genome Consortium for Active Teaching (GCAT), Department of Biology, Davidson College, Davidson, NC 28035.
Biochem Mol Biol Educ. 2004 Jul;32(4):217-27. doi: 10.1002/bmb.2004.494032040362.
In recent years, microarray analysis has become a key experimental tool, enabling the analysis of genome-wide patterns of gene expression. This review approaches the microarray revolution with a focus upon four topics: 1) the early development of this technology and its application to cancer diagnostics; 2) a primer of microarray research, designed to guide the beginner; 3) a highlight of the Genome Consortium for Active Teaching (GCAT), a worldwide consortium of faculty who are integrating microarrays into the undergraduate teaching laboratory; and 4) the use of microarrays in the biotechnology industry with a look forward to future applications. A central theme within this review is the profound relevance of new, bioinformatics-based, technologies to undergraduate students within the biosciences.
近年来，微阵列分析已成为一种关键的实验工具，能够对全基因组范围内的基因表达模式进行分析。本综述围绕四个主题探讨微阵列技术的变革：1）该技术的早期发展及其在癌症诊断中的应用；2）微阵列研究入门，旨在指导初学者；3）积极教学基因组联盟（GCAT）亮点，这是一个由全球范围内将微阵列技术整合到本科教学实验室的教师组成的联盟；4）微阵列技术在生物技术行业的应用以及对未来应用的展望。本综述的一个核心主题是基于生物信息学的新技术对生物科学领域本科学生的深远意义。
