单克隆抗体介导的对人乳头瘤病毒11型感染性的中和作用
Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11.
作者信息
Christensen N D, Kreider J W, Cladel N M, Patrick S D, Welsh P A
机构信息
Department of Pathology, Milton S. Hershey Medical Center, Pennsylvania 17033.
出版信息
J Virol. 1990 Nov;64(11):5678-81. doi: 10.1128/JVI.64.11.5678-5681.1990.
Abstract
Monoclonal antibodies recognizing human papillomavirus type 11 (HPV-11) were prepared from BALB/c mice immunized with intact HPV-11 virions obtained from morphologically transformed human foreskin xenografts grown subrenally in athymic mice. Four of five monoclonal antibodies that were reactive by enzyme-linked immunosorbent assay only to intact virions neutralized HPV-11 infectivity in the athymic mouse xenograft system.
摘要
从用在无胸腺小鼠肾下生长的形态学转化人包皮异种移植物中获得的完整11型人乳头瘤病毒（HPV - 11）免疫的BALB/c小鼠制备了识别HPV - 11的单克隆抗体。通过酶联免疫吸附测定仅对完整病毒颗粒有反应的5种单克隆抗体中的4种在无胸腺小鼠异种移植物系统中中和了HPV - 11的感染性。
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本文引用的文献
1
STUDIES ON THE MECHANISM RESPONSIBLE FOR THE SPONTANEOUS REGRESSION OF THE SHOPE RABBIT PAPILLOMA.关于肖普兔乳头瘤自发消退机制的研究。
Cancer Res. 1963 Oct;23:1593-9.
2
A quantitative in vitro focus assay for bovine papilloma virus.一种用于检测牛乳头瘤病毒的定量体外病灶测定法。
Virology. 1980 Jun;103(2):369-75. doi: 10.1016/0042-6822(80)90195-6.
3
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.T4基因编码艾滋病病毒受体，并在免疫系统和大脑中表达。
Cell. 1986 Nov 7;47(3):333-48. doi: 10.1016/0092-8674(86)90590-8.
4
Susceptibility of various human tissues to transformation in vivo with human papillomavirus type 11.人乳头瘤病毒11型在体内对各种人体组织的转化易感性。
Int J Cancer. 1987 Apr 15;39(4):459-65. doi: 10.1002/ijc.2910390409.
5
Laboratory production in vivo of infectious human papillomavirus type 11.人乳头瘤病毒11型感染性病毒在体内的实验室制备
J Virol. 1987 Feb;61(2):590-3. doi: 10.1128/JVI.61.2.590-593.1987.
6
Neutralizing antibodies to visna lentivirus: mechanism of action and possible role in virus persistence.抗维斯纳慢病毒的中和抗体：作用机制及在病毒持续存在中的可能作用
J Virol. 1986 Jul;59(1):37-44. doi: 10.1128/JVI.59.1.37-44.1986.
7
Production of a monoclonal antibody against an epitope on HeLa cells that is the functional poliovirus binding site.针对HeLa细胞上作为功能性脊髓灰质炎病毒结合位点的表位产生单克隆抗体。
J Gen Virol. 1985 Dec;66 ( Pt 12):2563-9. doi: 10.1099/0022-1317-66-12-2563.
8
Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata.
Nature. 1985;317(6038):639-41. doi: 10.1038/317639a0.
9
Antigenic analysis of a major neutralization site of herpes simplex virus glycoprotein D, using deletion mutants and monoclonal antibody-resistant mutants.利用缺失突变体和单克隆抗体抗性突变体对单纯疱疹病毒糖蛋白D主要中和位点进行抗原分析。
J Virol. 1988 Sep;62(9):3274-80. doi: 10.1128/JVI.62.9.3274-3280.1988.
10
A conformational immunogen on VP-2 of infectious bursal disease virus that induces virus-neutralizing antibodies that passively protect chickens.
J Gen Virol. 1989 Jun;70 ( Pt 6):1473-81. doi: 10.1099/0022-1317-70-6-1473.
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