Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia.
J Nat Prod. 2011 Jul 22;74(7):1613-20. doi: 10.1021/np200241c. Epub 2011 Jun 27.
From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multi-drug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
从黑山的夹竹桃科植物 Euphorbia dendroides 中分离得到了七种新的二萜类化合物[ jatrophanes（1-6）和 tigliane（7）]，并通过光谱技术阐明了它们的结构。研究了新化合物对四种人癌细胞系的生物活性。对最有效的 jatrophane 型化合物（2）及其结构密切相关的衍生物（1）进行了评估，以研究它们与紫杉醇和阿霉素在多药耐药癌细胞系中的相互作用。两种化合物均表现出很强的逆转作用，这是由于抑制了 P-糖蛋白的转运。
