Reading School of Pharmacy, University of Reading, Whiteknights, RG6 6AD Reading, United Kingdom.
Langmuir. 2011 Aug 2;27(15):9551-6. doi: 10.1021/la201385h. Epub 2011 Jun 27.
A novel approach has been developed to synthesize thiolated sub-100 nm organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane (MPTS) through its self-condensation in dimethylsulfoxide in contact with atmospheric oxygen. The formation of MPTS nanoparticles proceeds through the condensation of methoxysilane groups and simultaneous disulfide bridging caused by partial oxidation of thiol groups. These nanoparticles showed excellent colloidal stability in dilute aqueous dispersions but underwent further self-assembly into chains and necklaces at higher concentrations. They exhibited very good ability to adhere to ocular mucosal surfaces, which can find applications in drug delivery. The thiolated nanoparticles could also be easily modified through PEGylation resulting in a loss of their mucoadhesive properties.
一种新方法已经被开发出来，用于通过 3-巯丙基三甲氧基硅烷（MPTS）在二甲亚砜中的自缩合，与大气中的氧气接触，合成硫醇化的亚 100nm 有机硅纳米粒子。MPTS 纳米粒子的形成是通过甲氧基硅烷基团的缩合和由于巯基的部分氧化而引起的二硫键桥联来进行的。这些纳米粒子在稀水溶液中表现出极好的胶体稳定性，但在较高浓度下会进一步自组装成链和项链。它们表现出很好的黏附在眼部黏膜表面的能力，这可以在药物输送中找到应用。巯基化的纳米粒子也可以很容易地通过 PEG 化进行修饰，从而导致其黏膜黏附特性的丧失。
